Biography 

1. Research Areas

1. Endocytic Mechanism and Intracellular Drugs Delivery

2. Functional Antibody Development & Biomarker Discovery

2. Education

2001.9-2004.7, Ph.D in Cell Biology Major, Fourth Military Medical University

1995.9-1998.7, MA.Sc in Genetics Major, Jinlin University

1991.9-1995.7, B.S. in Genetics Major, Northwest Agriculture University

3. Professional Experience

2011.10- Present, Associate Professor in School of Medicine, Nankai University

2006.9-2009.12, Postdoc in Lund University Hospital

2005.9-2011.9, Associate Professor in Cell Engineer Research Center, Fourth Military Medical University

2000.9-2005.8, Lecturer in Cell Engineer Research Center, Fourth Military Medical University

1998.9-2000.8, Teaching Assistant in Department of Cell Biology, Fourth Military Medical University

4. Awards

1. 2010.9, WIPO-SIPO Award for Chinese Outstanding Patented Invention (Gold medal, No.3)

2. 2005.11, National Prize for Progress in Science and Technology (Second Award, No.10)

5. Social Service

Working Experience Related with Profession:

1. Fund Reviewer: Natural Science Foundation project; Ministry of Education Project.

2. Peer Reviewer: Cancer Sci, Int J Oncol, Oncol Lett, Oncol Rep.etc.

3. Committee Member: Chinese Society for Cell Biology (Division of Cell Engineering and Transgenic Biology), China Medicinal Biotech Association (Division of McAb), Chinese Anti-Cancer Association (Division of Tumor Marker)

Research & Achievements

Peer-Reviewed Journal Papers

1．Liu J, Zhang Q, Chen H, Gao Z, Li Y, Sun Z, Xiang R, Zhang S*. Phage display library selection of a hypoxia-binding scFv antibody for liver cancer metabolic marker discovery. Oncotarget. 2016, 7(25):38105-38121.

2．Chen H, Gao Z, He C, Xiang R, van Kuppevelt TH, Belting M, Zhang S*. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA. Exp Cell Res. 2016, 343(2):223-36.

3．Zhang Q, Li D, Bai C, Zhang W, Zheng S, Zhang P*, Zhang S*. Clinical prognostic factors for time to positivity in cancer patients with bloodstream infections. Infection. 2016, 44(5):583–588.

4．Zhao P, Zhang W, Wang SJ, Yu XL, Tang J, Huang W, Li Y, Cui HY, Guo YS, Tavernier J, Zhang SH*, Jiang JL*, Chen ZN*. HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in HCC cells. Hepatology. 2011,54(6):2012-24.

5. Zhao P, Zhang W, Tang J, Ma XK, Li Y, Jiang JL, Zhang SH*,Chen ZN*. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. Cancer Sci.2010,101(2):387–395.

6. Zhang Q*, Zhang SH*, Su MQ, Bao GQ, Liu JY, Yi J, Shen JJ, Hao XK. Guided selection of an anti-gamma-seminoprotein human Fab for antibody directed enzyme prodrug therapy of prostate cancer. Cancer Immunol Immunother.2007,56(4):477-89.

7. Zhang SH, Xing JL, Zhang Q, Song F, Li Y, Yang XM, Chen ZN. Optimal design of Ig 5’primers for construction of diverse phage antibody library established to select anti-HAb18GEF and anti-DOTA-Y Fabs for hepatoma pretargeting RIT. Front Biosci, 2006,11,1733 -1749.

8. Wittrup A, Zhang SH, P. Kucharzewska, Johansson M, Welch J, Mörgelin M, Belting M,  Magnetic nanoparticle based isolation of endocytic vesicles reveals a functional role of the heat shock protein GRP75 in macromolecular delivery. Proc Natl Acad Sci U S A. 2010,107(30):13342-7.

9. Wittrup A, Zhang SH, ten Dam GB, van Kuppevelt TH, Bengtson P, Johansson M, Welch J, Mörgelin M, Belting M. ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican. J Biol Chem. 2009,284(47):32959-67.

Books and Chapters

1. Wittrup A, Zhang SH, Belting M，Studies of Proteoglycan Involvement in CPP-Mediated Delivery. Cell-Penetrating Peptides. Methods Mol Biol. 2011;683:99-115. Humana Press.

2. Zhang SH, The Sulfation Code Involving in GAG-Protein Interactions. 10000 Selected Problems in Sciences: Medicine. 2011, Science Press.

Patent Application and Grant

1.Inventor: 201610169372.6; 201610402641.9

2. Co-inventor: CN100586960C; CN100480388C; US07638619; CN1313159C; CN1303105C; CN1280414C; CN1281753C

Projects

1. National Science and Technology Major Project of China (2011ZX09506; 2009ZX09301)

2. National Natural Science Found of China (81373318; 30400246)

3. Natural Science Found of Tianjin (13JCYBJC21000; 6JCYBJC23900)

4. The Ministry of Education Fund of China (20130031120037; 033781)

Teaching

1. Undergraduate: Medical Cell Biology; Medical information Searching and Management.

2. Master: Progresses of Antibody and Vaccine Research; Research Progress of Cancer Biology; Introduction to Human Diseases.