Biography 

1. Research Areas

     Neural injury and repair

2. Education

1986.9-1989.7 Master in anthropology Major, Yanbian University

1996.2-1999.2 PhD in anatomy and histology Major, Inha University, Inchun, South Korea.

3. Professional Experience

2001.11- 2011.11 Associate Professor in School of Medicine, Nakai University

2011.12 - Present, Professor in School of Medicine, Nankai University

4. Awards

5. Social Service

Research & Achievements

Research Achievements

Peer-Reviewed Journal Papers

1.Feng G, Zhang J, Li Y, Nie Y, Zhu D, Wang R, Liu J, Gao J, Liu N, He N, Du W, Tao H, Che Y, Xu Y, Kong D, Zhao Q, Li Z. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI.ASN ASN.2015050578; published ahead of print February 11, 2016

2.Cao S, Su X, Zeng B, Yan H, Huang Y, Wang E, Yun H, Zhang Y, Liu F, Li W, Wei H, Che Y, Yang R. The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation. Cell Rep. 2016 Feb 2; 14(4): 695–707.

3.Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, Liu Y, Zhang Y, Liu F, Che Y, Zhang Z, Yang R. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015 21;5:18588.

4.Zhao Q, Che Y, Li Q, Zhang S, Gao YT, Wang Y, Wang X, Xi W, Zuo W, Li SJ. The voltage-gated proton channel Hv1 is expressed in pancreatic islet β-cells and regulates insulin secretion. Biochem Biophys Res Commun. 2015 25;468(4):746-51.

5.Ke T. Yang M. Mao D. Zhu M. Che Y. Kong D. Li C. Co-Transplantation of Skin-Derived Precursors and Collagen Sponge Facilitates Diabetic Wound Healing by Promoting Local Vascular Regeneration. Cell Physiol Biochem 2015;37:1725-1737

6.Mao D, Yao X, Feng G, Yang X, Mao L, Wang X, Ke T, Che Y, Kong D. Skin-derived precursor cells promote angiogenesis and stimulate proliferation of endogenous neural stem cells after cerebral infarction. Biomed Res Int. 2015; Epub 2015 Mar 26.

7.Xiaomin Su, Siping Min, shuisong cao, hui yian, yining zhao, hui li, Limin Chai, shiyue mei, jia yang, yuan zhang, Zhujun Zhang, Feifei Liu, Wei sun, yongzhe che, and Rongcun Yang. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Nature Communications 2014 Jul 16

8.Su X, Mei S, Liang X, Wang S, Liu J, Zhang Y, Bao Y, Chen Y, Che Y, Chunhua Zhao R, Zhang Z, Yang R. Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors. J Leukoc Biol. 2014 96(1):17-26

9.Feng G, Mao D, Che Y, Su W, Wang Y, Xu Y, Fan Y, Zhao H, Kong D, Xu Y, Li Z. The phenotypic fate of bone marrow-derived stem cells in acute kidney injury. Cell Physiol Biochem. 2013;32(5):1517-27.

10.Jingyi Liu,Zhujun Zhang, Limin Chai, Yongzhe Che, Siping Min, Rongcun Yang Identification and characterization of a unique leucine-rich repeat protein (LRRC33) that inhibits Toll-like receptor-mediated NF-κB activation. Biochem Biophys Res Commun 2013,434(1):28-34

11.Min S, Liang X, Zhang M, Zhang Y, Mei S, Liu J, Liu J, Su X, Cao S, Zhong X, Li Y, Sun J, Liu Q, Jiang X, Che Y, Yang R. Multiple Tumor-Associated MicroRNAs Modulate the Survival and Longevity of Dendritic Cells by Targeting YWHAZ and Bcl2 Signaling Pathways. J Immunol. 2013 190(5):2437-2447

12.Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2013 ; 97(2):208-18.

13.Clinicopathological and biological significance of human voltage-gated proton channel Hv1 over-expression in breast cancer. Wang Yifan, Li Shujie, Wu Xiang, Che Yongzhe, Li Qiang. J Biol Chem. 2012, 2,24 

14.Preparation and evaluation of magnetic nanoparticles for cell labeling. Wang Y, Wang Y, Wang L, Che Y, Li Z, Kong D. J Nanosci Nanotechnol. 2011，11(5):3749-56.

15.Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis. Wang Y, Li SJ, Pan J, Che Y, Yin J, Zhao Q. Biochem Biophys Res Commun. 2011 26;412(2):353-359.

16.SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Liu X, Duan B, Cheng Z, Jia X, Mao L, Fu H, Che Y, Ou L, Liu L, Kong D. Protein cell，2011,2（10）：845-854

Projects

Projects

[1]     2010.1-2012.12. Experimental Study of Parthenogenetic Embryonic Stem Cell Transplantation on Myocardial Infarction in Mice, National Natural Science Foundation of China

[2] 2015.1-2017.12 The role of novel immunoreceptor receptor LRRC19-mediated specific immunity in the development and progression of enterocolitis, Ministry of Science and Technology major research program

[3] 2014.10-2017.9 Regulation of Epigenetic Modification on Myeloblast Inhibitory Cell Polarization in Tumor and Non-tumor Environment. International Cooperation and Exchange Program.

[4] 2011-2014 Application of pluripotent stem cell-specific differentiation and epigenetic regulation in the treatment of diabetes mellitus,National Major Scientific Research Project

Teaching

Teaching

[1] Undergraduate: Systematic Anatomy, Topographic Anatomy, Neural Anatomy.

[2] Master: New progress of neural injury and repair