Biography

1.Research Interest

a)Tumor Control Theory and Therapeutics

b)Biomedical photonics

2.Educational Background

1981.9-1989.7 Tianjin Medical University, Department of medicine, Master of Medicine

3.Work Experience

1989-1991 The second center hospital, physician

1991-1996 The second center hospital, attending physician

1996-1999 The second center hospital, associate chief physician

1999-2003 The second center hospital, associate chief physician, Vice President

2003-2011 Tianjin Union Medical Center, associate chief physician, Vice President

2011-2014.8 Tianjin Union Medical Center, chief physician, Vice President

2014.8-present Tianjin Union Medical Center, chief physician, President

Achievements

Peer-Reviewed Journal Papers

1.Real-time subcellular imaging based on graphene biosensors. Lixun Sun(#); Yuquan Zhang(#); Yijia Wang; Yong Yang(*); Chonglei Zhang; Xiaoyu Weng; Siwei Zhu; Xiaocong Yuan(*) Nanoscale, 2018, 10: 1759~1765.

2.Research of detection depth for graphene-based optical sensor. Yong Yang(*)，Jialve Sun，Lu Liu，Siwei Zhu，Xiaocong Yuan(*) Optics Communications，2018，411：143~147.

3.Dynamic plasmonic nano-traps for single molecule surface-enhanced Raman scattering. Yuquan Zhang，Junfeng Shen，Zhenwei Xie，Xiujie Dou，Changjun Min(*)，Ting Lei，Jun Liu，Siwei Zhu，Xiaocong Yuan(*). Nanoscale，2017.6.14，9：10694~10700

4.Improved Interference configuration for structured illumination microscopy

Chen Houkai，Wei Shibiao，Wu Xiaojing，Yang Yong，Zhang Yuquan，Du Luping，Liu Jun(*)，Zhu Siwei，Yuan Xiaocong(*). Optics Communications，2017.2.1，384：59~64, SCI.

5.Manipulating orbital angular momentum of light with tailored in-plane polarization states. Du Luping(#)，Zhongsheng Man(#)，Yuquan Zhang(#)，Changjun Min(*)，Siwei Zhu，Xiaocong Yuan(*). Scientific Reports，2017.1.23，7：41001~41001; SCI

6.Microscopic surface plasmon enhanced raman spectral imaging. Qiuyue Sun，Yuquan Zhang，Lixun Sun，Yong Yang(*)，Changjun Min，Siwei Zhu，Xiaocong Yuan(*). Optics communications，2017.1.1，392：64~67; SCI.

7.Refractive index mapping of single cells with a graphene-based optical sensor

Lixun Sun，Yuquan Zhang，Yijia Wang，Chonglei Zhang，Changjun Min，Yong Yang(*)，Siwei Zhu，Xiaocong Yuan(*). Sensors and Actuators B: Chemical，2017.5.1，242：41~46.

8.Structured Illumination for Wide-Field Raman Imaging of Cell Membranes

Houkai Chen，Siqi Wang，Yuquan Zhang(*)，Yong Yang，Hui Fang，Siwei Zhu，Xiaocong Yuan(*). Optics Communications，2017.11.1，402：221~225.

9.Chemically modified graphene films forhigh-performance optical NO2 sensors

Fei Xing，Shan Zhang，Yong Yang(*)，Wenshuai Jiang，Zhibo Liu，Siwei Zhu，Xiaocong Yuan(*). Analyst，2016.5.19，141：4725~4732; SCI.

10.Plasmonic patterned wide-field gap mode mechanism for surface enhanced Raman imaging. Houkai Chen，Luping Du，Xiaojing Wu，Siwei Zhu，Yong Yang，Hui Fang，Xiaocong Yuan(*). Applied Physics Letters，2016.12.28，109：261904~261904; SCI.

11.Sub-wavelength sized transversely polarized optical needle with exceptionally suppressed side-lobes. Zhongsheng Man，Changjun Min(*)，Luping Du，Yuquan Zhang，Siwei Zhu，Xiaocong Yuan(*). Opt Express，2016.1.25，24（2）：874~874; SCI.

12.Ultra-high sensitivity, multi-parameter monitoring of dynamical gas parameters using a reduced graphene oxide microcavity. Fei Xing，Yong Yang(*)，Junfeng Shen，Wenshuai Jiang，Zhibo Liu，Siwei Zhu，Xiaocong Yuan(*). Sensors and Actuators B: Chemical，2016.11.1，235：474~480; SCI.

13.A label-free approach to kinetic analysis and high multiplex detection of targeted drugs with phase surface plasmon resonance imaging. Yijia Wang，Chonglei Zhang，Yuquan Zhang，Hui Fang，Changjun Min，Siwei Zhu(*)，X.-C.Yuan. Analytical Methods，2015.4.1，2015（7）：1738~1744; SCI.

14.onic Spanner for Metal Particle Manipulation. Y. Q. Zhang(#)，W. Shi(#)，Z. Shen，Z. S. Man，C. J. Min(*)，J. F. Shen，S. W. Zhu，H. P. Urbach，X.-C. Yuan(*). Scientific Reports，2015.10.10，5（1）：15446~15446; SCI.

15.Investigation of phase SPR biosensor for efficient targeted drug screening with high sensitivity and stability. Y. J. Wang，C. L.Zhang，Y. Q. Zhang，H. Fang，C. J. Min，S. W. Zhu(*)，X.-C. Yuan(*). Sensors and Actuators B: Chemical，2015.3.31，209（1）：313~322; SCI.

16.PGCCs Generating Erythrocytes to Form VM Structure Contributes to Tumor Blood Supply. Shiwu Zhang(*)，Xiaochun Xu，Siwei Zhu，Jun Liu. BioMed Research International，2015.2.10，2014（1）; SCI.

17.A meta-analysis of the relationship between RARβ gene promoter methylation and non-small cell lung cancer. Hua F(#)，Fang N(#)，Li X，Zhu S，Zhang W(*)，Gu J(*). PLoS One，2014.5.5，9（5）; SCI.

18.Dynamic cosine-Gauss plasmonic beam through phase control. Xiao, Kai，Wei, Shibiao，Min, Changjun(*)，Yuan, Guanghui，Zhu, S. W.，Lei, T.(*)，Yuan, X. -C. Optics Express，2014.6.2，22（11）：13541~13546; SCI.

19.Dynamic plasmonic beam shaping by vector beams with arbitrary locally linear polarization states. Man, Zhongsheng，Du, Luping，Min, Changjun(*)，Zhang, Yuquan，Zhang, Chonglei，Zhu, Siwei，Urbach, H. Paul，Yuan, X. -C.(*) Applied Physics Letters，2014.7.7，105（1）; SCI.

20.Effect of amifostine in head and neck cancer patients treated with radiotherapy: a systematic review and meta-analysis based on randomized controlled trials. Gu J(#)，Zhu S(#)，Li X，Wu H，Li Y，Hua F(*) PLoS One，2014.5.2，9（5） ; SCI

21.Engineered Tumor Cell Apoptosis Monitoring Method Based on Dynamic Laser Tweezers. Zhang, Yuquan，Wu, Xiaojing，Min, Changjun，Zhu, Siwei(*)，Urbach, H. Paul，Yuan, Xiaocong(*) Biomed Research International，2014.1.1，2014 ; SCI

22.Measurement of the microscopic viscosities of microfluids with a dynamic optical tweezers system. Zhang, Yuquan(*)，Wu, Xiaojing，Wang, Yijia，Zhu, Siwei(*)，Gao, Bruce Z.，Yuan, X-C(*) Laser Physics，2014.4.7，24（1） ; SCI

23.Phase-stepping technique for highly sensitive microscopic surface plasmon resonance biosensor. Zhang, Chonglei(*)，Wang, Rong，Wang, Yijia，Zhu, Siwei，Min, Changjun(*)，Yuan, X. -C. (*) Applied Optics，2014.2.10，53（5）：836~840 ; SCI

24.Plasmonic Hybridization Induced Trapping and Manipulation of a Single Au Nanowire on a Metallic Surface. Zhang, Yuquan，Wang, Jian，Shen, Junfeng，Man, Zhongsheng，Shi, Wei，Min, Changjun(*)，Yuan, Guanghui，Zhu, Siwei，Urbach, H. Paul，Yuan, Xiaocong(*) Nano Letters，2014.10.10，14（11）：6430~6436 ; SCI

25.Quantitative Diagnosis of Colorectal Polyps by Spectral Domain Optical Coherence Tomography. Chen Wang，Qinqin Zhang，XiaojingWu，Tao Tang，Hong Liu(*)，S. W. Zhu，Bruce Z. Gao，X.-C. Yuan(*) BioMed Research International，2014.4.9，2014 ; SCI

26.Quantitative Diagnosis of Colorectal Polyps by Spectral Domain Optical Coherence Tomography. Wang, Chen; Zhang, Qinqin; Wu, Xiaojing; Tang, Tao; *Liu, Hong; Zhu, S. W.; Gao, Bruce Z.; Yuan, X. -C. Biomed Research International, 2014, 2014 ; SCI

27.Scattering Coefficients of Mice Organs Categorized Pathologically by Spectral Domain Optical Coherence Tomography. Zhang, Q. Q.，Wu, X. J.，Wang, C.，Zhu, S. W.，Wang, Y. L.(*)，Gao, Bruce Z.，Yuan, X. -C.(*) Biomed Research International，2014.4.15，2014 ; SCI

28.Tight focusing of quasi-cylindrically polarized beams. Man, Zhongsheng，Min, Changjun(*)，Zhu, Siwei，Yuan, X. -C.(*) Journal of the Optical Society of America A-Optics Image Science and Vision，2014.2.1，31（2）：373~378 ; SCI

29.Association between P(16INK4a) promoter methylation and non-small cell lung cancer: a meta-analysis. Gu J，Wen Y，Zhu S，Hua F，Zhao H，Xu H，You J，Sun L，Wang W，Chen J，Zhou Q(*) PLoS One，2013.4.5，8（4）：60107~60107 ; SCI

30.Dynamic optical tweezers based assay for monitoring early drug resistance. Xiaojing Wu，Yuquan Zhang，Changjun Min，Siwei Zhu，Jie Feng(*)，X-C Yuan(*) Laser Phys. Lett.，2013.5.8，10（1）：65604~65604 ; SCI

31.Perimental approach to the microscopic phase-sensitive surface plasmon resonance biosensor. Chonglei Zhang，Rong Wang，Changjun Min(*)，Siwei Zhu，X.-C. Yuan(*) Applied physics letters，2013.1.7，102（1）：11114~11114 ; SCI

32.Focused plasmonic trapping of metallic particles. Changjun Min，Zhe Shen，Junfeng Shen，Yuquan Zhang，Hui Fang，Guanghui Yuan，Luping Du，Siwei Zhu，Ting Lei，Xiaocong Yuan(*) Natrue Communications，2013.12.9，4（1）：2891~2891 ; SCI

33.Plasmonic petal-shaped beam for microscopic phase-sensitive SPR biosensor with ultrahigh sensitivity. Wang R，Du L，Zhang C，Man Z，Wang Y，Wei S，Min C，Zhu S，Yuan XC(*) Opt Lett，2013.11.15，38（22）：4770~4770 ; SCI

Projects

1.National Natural Science Foundation of China, 11774256, Photoacoustic microscopy imaging based on graphene refractive index sensing technology and applied investigation

2.National Natural Science Foundation of China, 61377052, Research and application of hybrid surface plasmon enhanced highly sensitive Raman spectroscopy

3.The Key R & D program of Tianjin, 17YFZCSY00700, The application of methylation of Septin 9 in screening and prediction of recurrence of colorectal cancer

4.National key Basic Research Program of China (973Program), 2015CB352000, Nanometer resolution fast optical imaging mechanism and basic research

5.National Natural Science Foundation of China, 61427819, Development of a novel optical microscope with nano-meter resolution assisted by surface enhanced Raman scattering

6.The Key R & D program of Tianjin, 12ZCDZSY17100, Clinical research on early diagnosis and treatment of colorectal cancer

7.Natural Science Foundation of Tianjin, BE023841, Novel high-sensitive and high-throughput SPR sensing and imaging based on all-optically manipulated SPP

8.National Natural Science Foundation of China, 61036013, Novel high-sensitive and high-throughput SPR sensing and imaging based on all-optically manipulated SPP

9.National Natural Science Foundation of China, 60778045, Micro particle sorting technique based on optical tweezers lattices