Biography 

1. Research Areas

     Mechanism of organ fibrosis; Tumor microenvironment; Nanotechnology application in the diagnosis and treatment of cancer

2. Education

1991.7-1998.7  Master Degree in Clinical Medicine, Xiangya Medical School

2001.8-2004.6  Doctor Degree in internal Medicine, Peking Union Hospital

3. Professional Experience

     1998.8- 2001.7   Resident, the 2nd Affiliated Hospital of Xiangya Medical

                    School, Central South University

     2004.7-2008.4   Post-doc Associate, the University of Pittsburgh, Medical

                    Center, Pathology Department

     2008.5-2013.12  Associate Professor, Nankai University, School of Medicine,

                    Pathology Department

     2013.12-        Professor, Nankai University, School of Medicine,

                    Pathology Department

4. Awards

[1] 2014 The new century excellent talent support program of the Ministry of Education

[2] 2009 Great Rivers Award/Postdoctoral Fellowship/ Portfolio by American Heart Associate

5. Social Service

Working Experience Related with Profession:

[1]     2010-Present, peer review expert of Natural Science Foundation project

Research & Achievements

Research Achievements

 2.Shen L, Li H, Shi Y, Wang D, Gong J, Xun J, Zhou S, Xiang R, Tan X#.M2 tumour-associated macrophages contribute to tumour progression via legumainremodelling the extracellular matrix in diffuse large B cell lymphoma.Sci Rep. 2016 Jul 28;6:30347.
 3. Shen L, Qin K, Wang D, Zhang Y, Bai N, Yang S, Luo Y, Xiang R, Tan X#. Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation. BiochimBiophysActa. 2014 Jul 25.
 4. Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X#, Xiang R#. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat Commun. 2014 Jun 27;5:4280.
 5. Zhang Y, Guo Q, Zhang Z, Bai N, Liu Z, Xiong M, Wei Y, Xiang R#, Tan X#. VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages. Mol Cancer Res. 2014 Aug;12(8):1181-91.
 7. Liu Z, Lv D, Liu S, Gong J, Wang D, Xiong M, Chen X, Xiang R, Tan X#. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS One. 2013;8(4):e60190. doi: 10.1371/journal.pone.0060190.
 8. Xiong M, Gong J, Liu Y, Xiang R, Tan X#. Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1107-15. 
 10. Zhang M, Liu M, Xiong M, Gong J, Tan X#. Schisandrachinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. J Ethnopharmacol. 2012 May 7;141(1):111-8.
 11. Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C.Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer BiolTher. 2012 Apr;13(6):435-42.
 12. Hu J, Qin K, Zhang Y, Gong J, Li N, Lv D, Xiang R, Tan X#. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. BiochemBiophys Res Commun. 2011 Aug 12;411(4):786-91.
 13. Jia X, Li X, Xu Y, Zhang S, Mou W, Liu Y, Liu Y, Lv D, Liu CH, Tan X, Xiang R, Li N. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol. 2011 Aug;3(4):230-8.
 14. Tan X, He W, Liu Y. Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009;76:1248-1257. (IF= 6.193)
 15. Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am SocNephrol. 2009;20:1907-1918. (IF= 7.689)
 16. Tan X, Wen X, Liu Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am SocNephrol. 2008;19:1741-1752. (IF= 7.689)
 17. Giannopoulou M*, Dai C*, Tan X*, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 2008;173:30-41. (*:co-first author) (IF= 5.673)
 18. Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, Liu Y. .tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. J Am SocNephrol. 2008;19:503-514. (IF= 7.689)
 19. Tan X, Li Y and Liu Y. Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis.J Steroid BiochemMol Biol. 2007: 103: 491-496. (IF= 2.655)
 20. Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.J Am SocNephrol. 2006;17:3382-3393(IF= 7.689)
 21. Tan X, Zheng FL, Yang JH, Duan L, Li Y, Zhou QG. Effect of BMP-7 on the transdifferentiation of cultured human tubular epithelial cell induced by TGF-beta1. ACTA ACADEMIAE MEDICINAE SINICAE, 2004;26:274-278.
 22. Tan X, Zheng FL, Zhou QG, Duan L, Li Y. Effect of bone morphogenetic protein-7 on monocyte chemoattractant protein-1 induced epithelial-myofibroblast transition and TGF-beta1-Smad 3 signaling pathway of HKC cells. National Journal of China. 2005;85: 2607-2612.
 23. Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. Am J Physiol Renal Physiol. 2006;290:F1234-1240. (IF=3.731)
 24. Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am SocNephrol. 2006;17:2781-2791. (IF= 7.689)
 25. Zhou QG, Zheng FL, Wen YB, Tan X, Duan L, Li Y. Altered expression of vascular endothelial growth factor and its receptors in transdifferentiated human proximal tubular epithelial cells induced by transforming growth factor beta1. ACTA ACADEMIAE MEDICINAE SINICAE.2005;27: 325-331.

Peer-Reviewed Journal Papers

[1] Plos One

[2] American Journal of Pathology

Projects

Projects

[1]     2013.1-2017.1. National Natural Science Foundation of China, PI

[2]   2004.12-2015.11 Grant-In-Aid, Abbott Laboratories, Accomplisher

Teaching

Teaching

[1]Undergraduate: Pathology

[2]Master: Pathological techniques