Biography 

1. Research Areas

  [1]The molecular mechanismofmutual regulation betweentumormicroenvironment and tumor stemcellsand the role of tumor stem cell in tumormetastasis and recurrence;

  [2]High throughput screening of tumor stem cell-specificsmall molecule drugs and tumor targeted therapy by nanoparticle as drug carrier;

  [3]Novel design and preparation of DNA vaccine against tumor and tumor associated macrophage(TAMs) and the molecular mechanism of antitumor fusion protein against cancer.

2. Education

  1982, M.D. Degree, Chongqing Medical College, Chongqing 400062, Sichuan, China

  1989, Master's Degree, Clinical Biochemistry, Chongqing Medical College, Chongqing 400062, Sichuan, China

  1992, Ph.D. Degree, Cell Biology and Experimental Nuclear Medicine, Shanghai Second Medical University, Shanghai 200025, China

4. Awards

  [1]2001AACR-Ortho-JanssenScholar Award by the American Association for Cancer Research

5. Social Service

Working Experience Related with Profession:

  [1] 2010-present: Evaluation expert of the National Natural Science foundation of China

  [2] 1999-2003: Reviewer for Nature Medicine, Nature Biotechnology, PNAS,Journal of Clinical Investigation,Oncogene, Cancer Research, Blood, Journal of Immunology, International Journal of Cancer, Clinical Cancer Research, Human Gene Therapy.

Research & Achievements

Peer-Reviewed Journal Papers

1.Luo D, Wang G, Shen W, Zhao S, Zhou W, Wan L, Yuan L, Yang S, Xiang R. Clinical significance and functional validation of PPA1 in various tumors. Cancer Med. 2016 Oct; 5(10):2800-2812.

2.Zhang Z, Yin J, Yang J, Shen W, Zhang C, Mou W, Luo J,4, Yan H, Sun P, Luo Y, Tian Y, Xiang R. miR-885-5p suppresses hepatocellular carcinoma metastasis and inhibits Wnt/β-catenin signaling pathway. Oncotarget 2016 Oct 12. Epub ahead of print].

3.Shen L, Li H, Shi Y, Wang D, Gong J, Xun J, Zhou S, Xiang R, Tan X.M 2tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma. Sci Rep. 2016 Jul 286:30347

4.Zhang J, Liu C, Shi W, Yang L, Zhang Q, Cui J, Fang Y, Li Y, Ren G1, Yang S, Xiang R.The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer. Oncotarget.2016 May 17. Epub ahead of print

5.Zhao S, Bai N, Cui J, Xiang R, Li N..Prediction of survival of diffuse large B-cell lymphoma patients via the expression of three inflammatory genes. Cancer Med. 2016 Aug5(8):1950-61

7.Zhao S, Dong X, Shen W, Ye Z, Xiang R. Machine learning-based classification of diffuse large B-cell lymphoma patients by eight gene expression profiles. Cancer Med. 2016 May;5(5):837-52

9.Chang A, Chen Y, Shen W, Gao R, Zhou W, Yang S, Liu Y, Luo Y, Chuang TH, Sun P, Liu C, Xiang R. Ifit1 Protects Against Lipopolysaccharide and D-galactosamine-Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway. J Infect Dis 2015 Nov 1212(9):1509-20

10.Xu Y, Zhang S, Niu H, Ye Y, Hu F, Chen S, Li X, Luo X, Jiang S, Liu Y, Chen Y, Li J, Xiang R, Li N.STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer. Sci Rep. 2015 Aug 10;5:11754.

11.Liu C, Li Z, Wang L, Tong L, He N, Chen Y, Liu Y, Wu Z, Sun P, Xiang R, Ren G, Su W.Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment.Biomed Res Int. 2015;2015:974615.

12.Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation.Shen L, Qin K, Wang D, Zhang Y, Bai N, Yang S, Luo Y, Xiang R, Tan X. Biochim Biophys Acta. 2014 Nov;1842(11):2087-95.

13.Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment. Mou W, Xu Y, Ye Y, Chen S, Li X, Gong K, Liu Y, Chen Y, Li X, Tian Y, Xiang R, Li N. Cancer Lett. 2015 Mar 28;358(2):115-23.

14.The transcriptional regulation of SOX2 on FOXA1 gene and its application in diagnosis of human breast and lung cancers.Li X, Chen S, Sun T, Xu Y, Chen Y, Liu Y, Xiang R, Li N. Clin Lab. 2014;60(6):909-18.

15.Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X, Xiang R. Nat Commun. 2014 Jun 27;5:4280. 

17.Yeh DW, Liu YL, Lo YC, Yuh CH, Yu GY, Lo JF, Luo Y, Xiang R, Chuang TH. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013 Dec 17 ;110(51):20711-6

19.Liu Z, Lv D, Liu S, Gong J, Wang D, Xiong M, Chen X, Xiang R, Tan X. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS One. 2013;8(4) :e60190

20.Li X, Xu Y, Chen Y, Chen S, Jia X, Sun T, Liu Y, Li X, Xiang R, Li N. SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network. Cancer Lett. 2013 Aug ; 19;336(2):379-89

21.Zhang C, Bai N, Chang A, Zhang Z, Yin J, Shen W, Tian Y, Xiang R, Liu C. ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes. Cell Mol Immunol. 2013 Jan; 10(1):84-94

22.Yang J, Liao D, Chen C, Liu Y, Chuang TH, Xiang R, Markowitz D, Reisfeld RA, Luo Y. Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells. 2013 Feb; 31(2):248-58

23.Su W, Wang L, Zhou M, Liu Z, Hu S, Tong L, Liu Y, Fan Y, Kong D, Zheng Y, Han Z, Wu JC, Xiang R, Li Z. Human embryonic stem cell-derived endothelial cells as cellular delivery vehicles for treatment of metastatic breast cancer. Cell Transplant. 2013; 22(11): 2079-90. 

24.Si Chen, Yingxi Xu, Yanan Chen,  Xuefei Li,  Wenjun Mou,  Lina Wang, Yanhua Liu, Ralph A. Reisfeld, Rong Xiang, Dan Lv, Na Li. SOX2 gene regulates the transcriptional network of oncogenes and inhibits tumorigenesis of human lung cancer cells. PLoS One. 2012;7(5):e36326 

26.Lina Wang, Si Chen, Mingna Zhang, Na Li, Yanan Chen, Weijun Su, Yanhua Liu, Dan  Lu, Sanglin Li, Yixuan Yang, Zongjin Li, Pengpeng Qu, Huaidong Hu*, Rong  Xiang*. Legumain: a Biomarker for the Diagnosis and Prognosis of Human Ovarian Cancer. J Cell Biochem. 2012 Aug;113(8):2679-86. 

27.Lina Wang*, Weijun Su*, Ze Liu, Manqian Zhou, Si Chen, Yanan Chen, Dan Lu, Yanhua Liu, Fan Yan, Joesph C. Wu, Rong Xiang, Zongjin Li. CD44 Antibody Targeted Liposome for Molecular Imaging and Therapy of Hepatocellular Carcinoma. Biomaterials. 2012 Jul;33(20):5107-14.

28.Li-Na Wang, Huai-Dong Hu, Feng Ye, Sang-Lin Li, Hong Ren, Da-Zhi Zhang, Yi-Xuan Yang, Rong Xiang. Quantitative Proteome Analysis of Ovarian Cancer Tissues using a Itraq Approach. J Cell Biochem. 2012 Dec;113(12):3762-72.

29.Manqian Zhou, Lina Wang, Weijun Su, Lingling Tong, Yanhua Liu, Fan Yan, Yizhou Zheng, Hui Zhao, Rong Xiang*, Zongjin Li*. Assessment of therapeutic efficacy of liposome mediated gene delivery by molecular imaging for cancer therapy. Journal of Biomedical Nanotechnology.  J Biomed Nanotechnol.  2012 Oct; 8 (5): 742-50.

30.Su W, Zhou M, Zheng Y, Fan Y, Wang L, Han Z, Kong D, Zhao RC, Wu JC, Xiang R, Li Z.. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation. Journal of Cellular Biochemistry.  2011 Mar;112(3):840-8.

31.Debbie Liao, Ze Liu, Wolfgang J. Wrasidlo, Yunping Luo, Giang Nguyen, Tingmei Chen, Rong Xiang* and Ralph A. Reisfeld*. Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model. Cancer Research. 2011 Sep 1;71 (17):5688-96. 

32.Congfeng Xu，Jin Liu, Li-Chung Hsu, Yunping Luo, Rong Xiang and Tsung-Hsien Chuang. Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. FASEB J. 2011 Aug; 25(8):2700-10. 

33.Junwei Hao, Denise Campagnolo, Ruolan Liu, Wenhua Piao, Samuel Shi, Baoyang Hu, Rong Xiang, Qinghua Zhou MD, Timothy Vollmer, Luc Van Kaer, Antonio La Cava, Fu-Dong Shi. Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Annals of neurology. 2011 Apr; 69(4):721-34. 

34.Jiajia Hu, Kunhua Qin, Yan Zhang, Junbo Gong, Na Li, Dan Lv, Rong Xiang and Xiaoyue Tan. Downregulation of transcription factor Oct4 induces an epithelial-to- mesenchymal transition via enhancement of  Ca(2+) influx in breast cancer cells. Biochem Biophys Res Commun. 2011 Aug 12; 411(4):786-91. 

35.Debbie Liao, Ze Liu, Wolfgang Wrasidlo, Tingmei Chen, Yunping Luo, Rong Xiang and Ralph A. Reisfeld. Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine. 2011 Dec;7(6):665-73. 

36.Xianpei Jia, Xuefei Li, Yingxi Xu, Shu Zhang, Wenjun Mou, Yanhua Liu, Yin Liu, Dan Lv, Cheng-Hu Liu, Xiaoyue Tan, Rong Xiang and Na Li. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. Journal of Molecular Cell Biology. 2011 Aug;3(4):230-8. 

37.Xiang R, Liao D, Cheng T, Zhou H, Shi Q, Chuang TS, Markowitz D, Reisfeld RA, Luo Y. Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer. 2011 Apr 26;104(9):1410-7. 

38.Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD.  Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology; J Exp Med. 2010 Aug 30;207(9):1907-21. 

39.Luo, Y., Zhou, H., Krueger, J., Kaplan, C., Liao, D., Markowitz, D., Liu, C., Chuang, TS., Xiang, R and Reisfeld, R.A.  The Role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression.  Oncogene, 4:29(5):662-73, 2010.

40.Wang Q, Ni H, Lan L, Wei X, Xiang R, Wang Y.; Fra-1 proto-oncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. Cell Res. 2010 Jun;20(6):701-12. 

41.Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA; Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS One. 2009 Nov 23;4(11):e7965.

42.Lee J, Hayashi M, Lo JF, Fearns C, Chu WM, Luo Y, Xiang R, Chuang TH. NF-kappaB activation primes cells to a pro-inflammatory polarized response to a TLR7 agonist. Biochem J. 2009 Jun 26;421(2):301-10. 

43.Hu P, Hu HD, Chen M, Peng ML, Tang L, Tang KF, Matsui M, Belladonna ML, Yoshimoto T, Zhang DZ, Xiang R, Ren H. Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma; Mol Immunol. 2009 May; 46(8-9):1654-62. 

Projects   

  [1] China and Thailand Biological Vaccine Transformation Medical Center.(Project leader)

Source of Funds: Science and Technology Assistance Program for Developing Countries

ProjectPeriod:2015.12-2018.11

  [2] Preparation of Novel pH - Sensitive Oral Nanoparticle DNA Vaccine

Source of Funds: National Natural Science Foundation of China

Project Period: 2013.01-2016.12

  [3] Regulatory mechanism of KDM6B on the development and progression of diffuse large B – cell

Source of Funds: National Natural Science Foundation of China

ProjectPeriod:2015.01-2018.12

  [4] Research in the Regulating Mechanism of Tumor Stem Cells in Solid Tumor Development. (Project leader)

Project ID: 2013CB967200

Source of Funds: National key basic research plan

Project Period: 2013/01-2017/08

  [5]The Regulating Mechanism of Tumor Microenvironment to Tumor Stem Cells and its New Therapy Strategy.( Project leader)

Source of Funds: Major project of National Natural Science foundation of China ProjectPeriod: 2009/01-2012/12

  [6] Mechanism of TAMs in the Tumor Microenvironment Mediating Cancer Cell Infiltration and Metastasis.( Project leader)

Project ID: BE021261

Source of Funds:Tianjin Science and Technology Support Key Project

ProjectPeriod:2007/10-2010/09

  [7] Research on Protein's Function in the Interaction Process of Tumor cells and Immune cells.(Project leader)

Project ID: 2007CB914804

Source of Funds: Subproject of National 973 Programme

ProjectPeriod: 2007-2012

  [8] Pre-clinical Research on the Cancer Gene Therapy Products.( Project participant)

Project ID: 2007AA021010

Source of Funds: Subproject of National 863 Programme

ProjectPeriod: 2007-2012

  [9] Experimental Research on the Isolation and Identification of New Specific Molecular  Markers of TAMs and its Targeting Therapy of Breast Cancer.( Project leader)

Project ID: 30672389

Source of Funds: National Natural Science found ofChina

ProjectPeriod: 2007/01-2009/12

  [10] Research on Legumain-targeted Liver Cancer Vaccine.(Project leader,finished)

Project ID: 30572116

Source of Funds: National Natural Science found ofChina

ProjectPeriod: 2006/01-2008/12

Teaching

  [1]Undergraduate:Advanced Oncology

  [2]Master:Immunology