Biography 

1. Research Areas

1) Epigenetic and genetic regulation on immune cells, especially myeloid derived immune cells.

2) Gut microbiota and human diseases, especially colon carcinoma.

2. Education

1996.9-2000.4, PhD in Sweden, Karolinska Institute

1986.9-1989.9, MS in China, Capital Medical Universiy

1978.9-1983.9, BS in China, Shandong University

3. Professional Experience

2005.9- Present, Professor in School of Medicine, Nankai University

2000.4-2003.6, Post-doctorate in the Johns Hopkins University School of Medicine.

2003.6-2006. 5, Lecture in the Johns Hopkins University School of Medicine

1983.9-1986.6, Lecturer in Capital Medical University

1983.9-1986.9, Medical doctor in the Center of Disease Control.

4. Social Service

Working Experience Related with Profession:

[1] 2007-present, member of the American Association of immunology.

[2] 2007-present, members of a council in the division of basic immunology, Chinese Society for Immunology.

[3] 2010-present , members of a council in the Tianjin Society for Immunology.

[5] 2010-present , members of a council in the Tianjin Society for Cellular Biology.

[6] 2005-Present, peer review expert of Natural Science Foundation project

[7] 2005-present, review expert of Ministry of Education of the People’s Republic of China.

Research & Achievements

Selected papers in Peer-Reviewed Journal Papers (more than 70 papers)

1.Cao S, Su X, Zeng B, Yan H, Huang Y, Wang E, Yun H, Zhang Y, Liu F, Li W, Wei H, Che Y, Yang R*. The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation. Cell Rep. 2016 Jan 13. pii: S2211-1247(15)01524-7. doi: 10.1016/j.celrep.2015.12.070. [Epub ahead of print]

2.Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, Liu Y, Zhang Y, Liu F, Che Y, Zhang Z, Yang R*. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus. Sci Rep. 2015 Dec 21;5:18588. doi: 10.1038/srep18588.

3.Mei S, Liu Y, Wu X, He Q, Min S, Li L, Zhang Y, Yang R*.TNF-α-mediated microRNA-136 induces differentiation of myeloid cells by targeting NFIA. J Leukoc Biol. 2015 Sep 1. pii: jlb.1A0115-032RR. [Epub ahead of print]

4.Liu Y, Liang X, Yang R*. Identification of peculiar and common effects of histone modifications on transcription.. J Theor Biol. 2015 Sep 7;380:24-39. doi: 10.1016/j.jtbi.2015.04.040. Epub 2015 May 20.

5.Xu, Min S, Cao S, Yan H, Zhao Y, Li H, Chai L, Mei S, Yang J, Zhang Y, Zhang Z, Liu F, Sun W, Che Y, Yang R*. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. Nat Commun. 2014 Jul 16;5:4434. doi: 10.1038/ncomms5434. （Sci-IF, 11.8）

6.Min S, Liang X, Zhang M, Zhang Y, Mei S, Liu J, Liu J, Su X, Cao S, Zhong X, Li Y, Sun J,Liu Q, Jiang X, Che Y, Yang R*, Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways. J Immunol, 190(5):2437-46, 2013. (SCI-IF, 5.75).

7.Zhang M, Liu Q, Mi S, Liang X, Zhang Z, Su X, Liu J, Chen Y, Wang M, Zhang Y, Guo F, Zhang Z and Rongcun Yang*, Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol. 2011 Apr 15; 186(8):4716-24. Epub 2011 Mar 7. (SCI-IF: 5.75).

8.Jing Z, Yuan X, Zhang J, Huang X, Zhang Z, Liu J, Zhang M, Oyang J, Zhang Y, Zhang Z, Rongcun Yang* Chromosome 1 open reading frame 190 promotes activation of NF-κB canonical pathway and resistance of dendritic cells to tumor-associated inhibition in vitro. J Immunol. 2010 Dec 1;185(11):6719-27. Epub 2010 Nov 3. (SCI-IF: 5.75).

9.Zhang Z, Liu Q, Che Y, Yuan X, Dai L, Zeng B, Jiao G, Zhang Y, Wu X, Yu Y, Zhang Y, Yang R*. Antigen presentation by dendritic cells in tumors is disrupted by altered metabolism that involves pyruvate kinase M2 and its interaction with SOCS3. Cancer Res. 2010 Jan 1;70(1):89-98. Epub 2009 Dec 8. （Sci-IF, 8.2）

10.Zhang Z, Zeng B, Zhang Z, Jiao G, Li H, Jing Z, Ouyang J, Yuan X, Chai L, Che Y, Zhang Y, Yang R*. Suppressor of cytokine signaling 3 promotes bone marrow cells to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression. Cancer Res. 2009 Feb 15;69(4):1578-86. Epub 2009 Feb 3. （Sci-IF, 8.2）

Projects

Ongoing projects

2017-2019, Regulation of gut microbiota on the gut immune cells, Natural Science Foundation project.

2015-2017,Effects of LRRC19 on colitis carcinoma, Natural Science Foundation project.

2015-2017, Genetic and epigenetic modification on the myeloid derived suppressor cells, Natural Science Foundation project.

2014-2018, Role of STAT3 in the epigenetic modification, Natural Science Foundation project.

2017-2022, Epigenetic markers of colon carcinoms, “973’ Program in Minitry of Science and Technology of the People’s Republic of China.

Finished projects: Natural Science Foundation projects (5 projects); Minitry of Science and Technology of the People’s Republic of China“973’ Program (1 project) and “863” program (3 projects).

Teaching

Teaching

[1]Undergraduate: Basic Immunology

[2]PhD: Advance of Immunology