I. Biography 

1. Research Areas

  Cancer biology; Cancer stem cells and tumour microenvironment; Targeted tumour therapy

2. Education

2002-2008Ph.D.,physiology & Integrative Biology

Rutgers, the State University of New Jersey& University of Medicine and Dentistry of New Jersey(Piscataway, NJ, USA)

       1993-1998B.S., Maternal andChild Medicine

Henan Medical University (Zhengzhou,China).

3. Professional Experience

2011-present Associate Professor

School of Medicine, Nankai University, Tianjin, China

2008-2011     Assistant Professor

School of Medicine, Nankai University, Tianjin, China

4. Awards

5. Social Service

[1]   2012-Present, peer review expert of Natural Science Foundation

project

II. Research & Achievements

1.Selected Peer-reviewed Publications:

 *Corresponding author

1)Shuangtao Zhao, Nan Bai, Jianlin Cui,Rong Xiang*andNa Li* Prediction of Survival of Diffuse-Large-B-Cell Lymphoma patientsvia the Expression of Three Inflammatory Genes.Cancer medicine2016 Aug;5(8):1950-61.

2)Yingxi Xu, Shu Zhang, Haiying Niu, Yujie Ye, Fen Hu, Si Chen, Xuefei Li, Xiaohe Luo， Shan Jiang, Yanhua Liu, Yanan Chen, Junying Li, Rong Xiang andNa Li*. STIM1 inhibits tumor growth but promotes the metastasis of prostate cancer by remodeling tumor microenvironment and enhancing epithelial-to-mesenchymal transition.Scientific Reports2015 Aug 10;5:11754.

3)Wenjun Mou, Yingxi Xu, Yujie Ye, Si Chen, Kangzi Gong, Yanan Chen, Yanhua Liu, Xiru Li, Yaping Tian, Rong Xiang andNa Li* Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophage to tumor microenvironment.Cancer Letters2015 Mar 28;358(2):115-23.

4)Weijun Su, Si Chen, Na Li*. The potential role of SOX2 in the anti-apoptosis property of cancer cells.Cancer Cell & Microenvironment 2014; 1: e253.

6Xuefei Li,Si Chen, Tongchao Sun, Yingxi Xu, Yanan Chen,Yanhua Liu, Rong Xiang andNa Li* The negative regulation effect of SOX2 on FOXA1 gene expression and its application in the diagnosis of human breast and lung cancers.Clinical Laboratory 2014; 60(6):909-18.

7)Xuefei Li, Yingxi Xu, Yanan Chen, Si Chen, Xianpei Jia, Tongchao Sun, Yanhua Liu, Xiru Li, Rong Xiang*andNa Li*. SOX2 promotes tumor metastasis by stimulatingepithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network.Cancer Letters 2013 Aug 19;336(2):379-89.

8)Si Chen, Yingxi Xu, Yanan Chen, Xuefei Li, Wenjun Mou, Lina Wang, Yanhua Liu, Ralph A. Reisfeld, Rong Xiang, Dan Lv* andNa Li*. SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells.PLOS one 2012 7(5):e36326; 2012 May 15.

9)Xianpei Jia, Xuefei Li, Yingxi Xu, Shu Zhang, Wenjun Mou, Yanhua Liu, Yin Liu, Dan Lv, Cheng-Hu Liu, Xiaoyue Tan, Rong Xiang,Na Li*. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell.Journal of Molecular Cell Biology 2011 Aug;3(4):230-8.

10Xiaohong Shen‡, Na Li‡, Hui Li, Ti Zhang, Feng Wang, Qiang Li.Increased prevalence of T regulatory cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma.Journal of Cancer Research and Clinical Oncology2010 Nov;136(11):1745-54. ‡Co-first author

11Na Li, Peihui Lin, Chuanxi Cai, Zui Pan, Noah Weisleder, Jianjie Ma.The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells.Am. J. Physiol.-Cell Physiology2009 Feb; 296(2):C267-72.

12)Na Li, Lin Zheng, Peihui Lin, David Danielpour, Zui Pan, Jianjie Ma. Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells.J. Cell Physiol.2008 Jul;216(1):172-9.

13)J Yang,Z Zhang,C Chen,Y Liu,Q Si,T-H Chuang,N Li,A Gomez-Cabrero,R A Reisfeld,R Xiang andY Luo.MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene. 2014 Jun 5;33(23):3014-23.

14)Yingxi Xu, Rong Liao,Na Li, Rong Xiang*, Peiqing Sun*. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. 2014 Dec 30;5(24):12555-72.

15)Yingxi Xu,Na Li, Rong Xiang, Peiqing Sun*. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends in biochemical sciences 2014 Jun;39(6):268-76.

16)Wei Wei, Hongyue Li,Na Li, Huihui Sun, Qiang Li, Xiaohong Shen. WNT5A/JNK signaling regulates pancreatic cancer cells migration by Phosphorylating Paxillin.Pancreatology. 2013 Jul-Aug;13(4):384-92.

17)Wei, Wei; Sun, Hui-Hui;Li, Na; Li, Hong-Yue; Li, Xin; Li, Qiang; Shen, Xiao-Hong*, WNT5A modulates cell cycle progression and contributes to the chemoresistance in pancreatic cancer cells, Hepatobiliary and Pancreatic Diseases International, 13(5), pp 529-538, 2014/10/15.

18)Andoria Tjondrokoesoemo,Na Li, Pei-Hui Lin, Zui Pan, Chrisopher J Ferrante, Natalia Shirokova, Marco Brotto, Noah Weisleder and Jianjie Ma. Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium sparks signaling in adult mammalian skeletal muscle. J. Biol. Chem. 2013 Jan 25;288(4):2103-9.

20)Zhuhong Zhang, Jing Yin, Chunyan Zhang, Ning Liang, Nan Bai, Antao Chang, Yanhua Liu, Zongjin Li, Xiaoyue Tan,Na Li, Dan Lv, Rong Xiang, Yaping Tian, and Chenghu Liu. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer Biology & Therapy 2012 Apr;13(6):435-42.

21)Jiajia Hu, Kunhua Qin, Yan Zhang, Junbo Gong,Na Li, Dan Lv, Rong Xiang and Xiaoyue Tan. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca(2+) influx in breast cancer cells. Biochem Biophys Res Commun. 2011 Aug 12; 411(4):786-91.

22)Hong-Min Ni, Catherine J. Baty,Na Li, Wentao Gao, Wen-Xing Ding, Min Li, Xiaoyun Chen, Jianjie Ma, George K. Michalopoulos and Xiao-Ming Yin. Bid Regulates Murine Hepatocyte Proliferation by Controlling ER Calcium Homeostasis. Hepatology2010 Jul;52(1):338-48.

23)Chuanxi Cai, Peihui Lin, King-Ho Cheung,Na Li, Christina Levchook, Zui Pan, Ferrante Christopher, Gabrielle L. Boulianne, J. Kevin Foskett, David Danielpour, and Jianjie Ma. The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. J. Biol. Chem. 2006 Jun;281(24):16649-55.

24)Peihui Lin, Zui Pan, Lin Zheng,Na Li, David Danielpour, Jianjie Ma. Overexpression of Bax sensitizes prostate cancer cells to TGF-beta induced apoptosis. Cell Research2005 Mar; 15(3):160-6.

2. Peer-Reviewed Journal Papers

[1] PLOS One,

[2]International Journal of Cancer etc.

[3]Oncotarget,

3. Books and Chapters

[1]Huanzhong Hu, Yangling Mou, .. Na Li et al., Experimental Course of Medical Function, Science Press, Beijing, China (2016).

III. Projects

[1]    2016/07–2020/06, Collaborated research funding between Tianjin People Hospital and Nanakai University “Signaling pathways in the regulation of osteoclast precursor cell migration in rheumatoid arthritis” Role: PI 

[2] 2016/01-2019/12，Natural Science Foundation of China- General Program “Cancer stem cells regulate angiogenesis through remodeling tumor microenvironment”，Role: PI 

[3]2014/01-2017/12，Natural Science Foundation of China- General Program “The transcriptional regulation effect of SOX2 on IL6R and its function in tumor metastasis”Role: PI

[4]2012/01-2014/12，China Ministry of Education Funding for returned overseas students to start research “The function of Sox2 in tumour metastasis” Role: PI     

[5]2011/01~2013/12，Natural Science Foundation of China- Young Scientist Program，Exploring the function of SOX2 in the anti-apoptosis property of cancer cells.Role: PI

[6]2010/06~2012/05,ChinaFundamental Research Funds for the Central Universities “Research on the role of SOX2 in theepithelial-to-mesenchymal transition during tumor metastasis”,Role: PI

[7]2010/01-2012/12,China Junior Faculty Funds,The function of Ca2+/Calcineurin-NFAT signal in prostate cancer stem cell.Role: PI

[8]2015/01-2016/12, Natural Science Foundation of China- Collaboration with Oversea & Hong Kong and MacaoProgram, “The role of microRNA in oncogene-induced senescence”,Role: Mainparticipator

[9] 2013/03-2017/08 China Major National Science and Technology Projects, “Study on the regulatory mechanism of cancer stem cells (CSCs) in the development of solid tumors”- Isolation, identification and molecular genetic characteristics of CSCs, Role: Main participator

[10] 2012/06- 2015/12, China International Cooperation Research Program, “Collaborative research for establishment of novel early warning system and prevention of breast cancer”, Role: Main participator

[11] 009/10 ~ 2012/09, Key Project of Tianjin Scientific & Technological Commission for China-Sweden Cooperation Research Program, Molecular Mechanism of Tumor Metastasis and Clinical Application in Diagnosis and Prognosis, Role: Main participator

IV. Teaching

[1] Undergraduate:

Pathophysiology (for 7-yearclinical medicine students)

Pathophysiology Experiment (for 7-yearclinical medicine students)

Experimental Course of Medical Function (for 5+3 clinical medicine students)

Pathophysiology and Pathophysiology Experiment (for oversea students)

[2] Master:

Frontier of Oncology