Biography 

1. Research Areas

[1]Molecular mechanisms of embryonic stem cells pluripotency

[2]Stem cells differentiation regulatory mechanisms

2. Education

[1]9/1996–7/2001   B.A. in Pharmacology, China Pharmaceutical University.

[2]9/2003–6/2008   Ph.D. in Cell Biology, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College.

3. Professional Experience

[1]7/2008–12/2011   Instructor in College of Life Sciences, Nankai University

[2]1/2012–6/2016    Associate Professor in College of Life Sciences, Nankai University

[3]8/2013–8/2014    Visiting Associate Professor in Yale University，United State

[4]6/2016–         Associate Professor in School of Medicine, Nankai University

4. Awards

[1]2012 Awards for Outstanding Achievements in teaching of Nankai University

[2]2016 Awards for Outstanding Achievements in young teacher teaching competition of Nankai University

5. Social Service

Working Experience Related with Profession:

[1]2013-   Advisory Board Member, OA Molecular & Cell Biology

[2]2014-  Editorial Board Members，Journal of Biochemistry and Molecular Biology Research

Research & Achievements

Peer-Reviewed Journal Papers

<!--[if !supportLists]-->[1]<!--[endif]-->Ningning He, Guowei Feng, Yang Li, Yang Xu, Xiaoyan Xie, Hui Wang, Yuebing Wang, Lailiang Ou, Xuetao Pei, Na Liu*, and Zongjin Li*. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95 Corresponding Author

<!--[if !supportLists]-->[2]<!--[endif]-->Na Liu,Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells. Sci Rep. 2016, 6:28739. First Author

<!--[if !supportLists]-->[3]<!--[endif]-->Dan J, Liu Y,Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19.First Author

<!--[if !supportLists]-->[4]<!--[endif]-->Yu Yin, Na Liu, Xiaoying Ye, Renpeng Guo, Jie Hao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein Cell. 2014 5(1):8-11 First Author

<!--[if !supportLists]-->[5]<!--[endif]-->Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R, Liu N*, Liu L*. , Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014;14(6):737-48. Corresponding Author

<!--[if !supportLists]-->[6]<!--[endif]-->Zhenrong Zhao, Xinghua Pan, Lin Liu* and Na Liu*. Telomere Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2014; 229(10):1323-9. Corresponding Author

<!--[if !supportLists]-->[7]<!--[endif]-->Na Liu, Lin Liu & Xinghua Pan. Single‑cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell. Mol. Life Sci. (2014) 71:2707–2715 First Author

<!--[if !supportLists]-->[8]<!--[endif]-->Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide Gene Expression Profiling Reveals Aberrant MAPK and Wnt Signaling Pathways Associated with Early Parthenogenesis. J Mol Cell Biol. 2010, 2(6):333-344. First Author

<!--[if !supportLists]-->[9]<!--[endif]-->Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition. J Cell Biochem. 2009, 106(6):1041-1047.First Author

<!--[if !supportLists]-->[10]<!--[endif]-->Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem.2008, 104(6):2348-2362.First Author

<!--[if !supportLists]-->[11]<!--[endif]-->Liu N, Lu M, Tian X, Han Z.Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286.First Author

<!--[if !supportLists]-->[12]<!--[endif]-->Liu N, Lu M. The signal transduction pathways and molecules for ES cells self-renewal, Chinese Science Bulletin. 2005, 50(8):721-726.First Author

<!--[if !supportLists]-->[13]<!--[endif]-->Guowei Feng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, Jie Gao, Na Liu, Ningning He, Wei Du, Hongyan Tao, Yongzhe Che, Yong Xu, Deling Kong, Qiang Zhao, and Zongjin Li*. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI. J Am Soc Nephrol. 2016, 27(8):2357-69. 

<!--[if !supportLists]-->[14]<!--[endif]-->Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015, 6(2):152-6.

<!--[if !supportLists]-->[15]<!--[endif]-->Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013, 23(1):162-6.

<!--[if !supportLists]-->[16]<!--[endif]-->Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells. 2013 31(11):2538-50.

<!--[if !supportLists]-->[17]<!--[endif]-->Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012 Dec 15; 13:36.

<!--[if !supportLists]-->[18]<!--[endif]-->Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N,Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2012, 1(11):1118-27.

<!--[if !supportLists]-->[19]<!--[endif]-->Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N,Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2012, 97(2):208-18.

<!--[if !supportLists]-->[20]<!--[endif]-->Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L.Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction. 2012; 27(5): 1411-1420.

<!--[if !supportLists]-->[21]<!--[endif]-->Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell Research. 2012; 22(4): 757-768.

<!--[if !supportLists]-->[22]<!--[endif]-->Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011, 21(5):779-92.

<!--[if !supportLists]-->[23]<!--[endif]-->Fang ZH, Dong CL, Chen Z, Zhou B, Liu N, Lan HF, Liang L, Liao WB, Zhang L, Han ZC. Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.J Cell Mol Med. 2009 13(8B):2039-52.

<!--[if !supportLists]-->[24]<!--[endif]-->Feng XM,Liu N, Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC. Regulation of the classⅡ and classⅠMHC pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008 14;367(3):553-9.

[25]Feng XM, Chen XL, Liu N,Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC. Interleukin-27 upregulates major histocompatibility complex class Ⅱ expression in primary human endoghelial cells through induction of major histocompatibility complex class Ⅱ trasactivator. Hum Immunol. 2007 68(12):965-72.

Books and Chapters:

[1]Yin Y, Liu N,Keefe D, and Liu L.Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.

[2]Yan Nie, Shuaiqiang Zhang, Na Liu,Zongjin Li, Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine.  Composition and Function of the Extracellular Matrix in the Human Body. INTECH, 2016

Projects

[1]Studies on the Relationship between Genomic Imprinting Gene H19 Expression and Pathenogenetic Embryonic Stem Cell Pluripotency.  (National Natural Science foundation of China, Grant No. 31000651)

[2]Studies on Dyskeratosis congenita.pathogenesis (Tianjin Natural Science foundation of China, Grant No. 14JCZDJC35200)

[3]Telomere-binding proteins and human diseases.(National Key Basic Research and Development Program of China, Grant No. 2012CB911200)

[4]Pork induced pluripotent stem cells and their differentiation. (National Key Basic Research and Development Program of China, Grant No. 2009CB941000)

Teaching

[1] Undergraduate: Cell Biology

[2] Master: Stem Cells and Regenerate Medicine