Biography 

1. Research Areas

[1].1 mechanisms of cardiovascular disease, especially the pathogenesis and treatment of atherosclerosis

[2].2 regulation of vascular function and pharmacological mechanism

2. Education

[1].Sept., 1992-July, 1996: Bachelor of Science, NankaiUniversity.

[2].Sept., 2000-Sept., 2003, Medical Master of physiopathology, Peking Union Medical College & Chinese Academy of Medic al Sciences

[3].Sept.., 2004-July, 2007: Ph. D. of Bioinformatics, College of Life Science, NankaiUniversity.

3. Professional Experience

[1].Sept., 1996-Jun., 2000: Research Assistant, State Key Lab of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Peking Union Medical College & Chinese Academy of Medic al Sciences

[2].Sept., 2003- Sept., 2004: Assistant Researcher & Research Secretary, State Key Lab of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Peking Union Medical College & Chinese Academy of Medic al Sciences

[3].July, 2004, - present: Lecture, - Associate Professor, School of Medicine, NankaiUniversity

4. Social Service

Working Experience Related with Profession:

[1]1999-Present, member of The Chinese Medical Association.

[2]2006-Present, member of The Chinese Biophysics Association.

Research & Achievements

Research Achievements

[1].Dong Li, Jie Gao, Xi Tan, Feng Gan, Michael P. Walsh, Yu Gui, Xi-long Zheng, MCP-1 inhibits vascular contractility of in mouse aorta. Manuscript in preparation.

[2].Pavneet Singh, Dong Li, Yu Gui, Xi-Long Zheng, Atrogin-1 ubiquitinates myocardin for proteosomal degradation with increased transcriptional activity, J Cell Physiol. 2016.

[3].Gui Y, Shi Z, Wang Z, Li JJ, Xu C, Tian R, Song X, Walsh MP, Li D, Gao J, Zheng XL The GPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER. J Cell Physiol. 2015 Apr; 230(4):885-95.

[4].Mengdan Liu, Wenlei Zhao, Lijuan Xu, Meiyi Tian, Yanran Tian, Wensu Yuan, Dong Li*, AICAR inhibits porcine coronary artery contraction induced by acetylcholine, The 15^th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).

[5].Wensu Yuan, Zengyong Wang, Jingjing Li, Lijuan Xu, Dong Li*, Estrogen Metabolite 2ME Prevents Hypertension in Hypertensive Rats. The 15th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).

[6].Ruijuan Tian, Zengyong Wang, Xinxing Song, Jingjing Li, Dong Li*，G-1 Inhibits Proliferation of Vascular Smooth Muscle Cells and Prevents Neointima Formation after Vessel Injury，The 15th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).

[7].Yuan Wensu, Xu Lijuan, Liu Mengdan, Wang Yuebing, Li Dong*, The Different Contraction between Rat Gastric Longitudinal and Circular Smooth Muscle Induced by Extracellular Nucleotides, Chinese Journal of Applied Physiology, (1)14-17，2014.

[8].Yuan W, Wang Z, Li J, Li D, Liu D, Bai G, Walsh MP, Gui Y, Zheng XL. Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways. IUBMB Life. 65(7):623-32. 2013.

[9].Tian Ruijuan, Wang Lifeng, Xu Lijuan, Wang Yuebing, Li Yang, Shi Yanrong, Zhu Yinjun, Lin Wanjun, Li Dong*, G-protein-coupled estrogen receptor-30 inhibit the proliferation of human uterine leiomyoma, Acta Scientiarum Naturalium Universitatis Nankaiensis ( Science Edition), 47(3):16-21, 2013

[10].Yuan W, Yu Y, Li J, Singh P, Li D, Gui Y, Zheng XL., Estrogen Metabolite 2-methoxyestradiol Prevents Hypertension in Deoxycorticosterone Acetate-salt Rats. Cardiovasc Drugs Ther. Feb; 27(1):17-22, 2013.

[11].Tian R, Wang Z, Shi Z, Li D, Wang Y, Zhu Y, Lin W, Gui Y, Zheng XL. Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. Fertil Steril. Jan; 99(1):256-63. 2013.

[12].Li H, Li J, Li Y, Singh P, Cao L, Xu LJ, Li D, Wang Y, Xie Z, Gui Y, Zheng XL. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. Dec 1; 303(11):H1319-31. 2012.

[13].Li J, Jiang J, Yin H, Wang L, Tian R, Li H, Wang Z, Li D, Wang Y, Gui Y, Walsh MP, Zheng XL. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension. Jul; 60(1):145-53. 2012.

[14].Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials. Apr; 33(10): 2880-91. 2012.

[15].Du F, Wang H, Zhao W, Li D, Kong D, Yang J, Zhang Y. Gradient nanofibrous chitosan/poly ?-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials. Jan; 33(3):762-70. 2012.

[16].Liang Cao, Jingjing Li, Dong Li*, AICAR Inhibits Proliferation of Smooth Muscle Cells From Porcine Coronary Arteries, 2011 China-Canada Symposium in Atherosclerosis and Cardiovascular Disease （Sept 23-25, Beijing, 2011）

[17].Ge Gao, Jing-Jing Li, Yuenan Li, Dong Li, Yuebing Wang, Lifeng Wang, Xiang D. Tang, Michael P. Walsh, Yu Gui, Xi-Long Zheng, Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility, Am J Physiol Heart Circ Physiol. 300: H1583-H1594. 2011.

[18].Wang, Guosong; Zhang, Hengyi; Li, Dong; Wang, Puyue; *Liu, Yu, Characterisation and antiproliferative activity of irinotecan and sulphonatocalixarene inclusion complex SUPRAMOLECULAR CHEMISTRY, 23(6), pp 441-446, 2011.

[19].Cui, L. H., Ren, Y. Y.,. Yin H., Li, D., and Zheng, X. L., increased expression of tuberin in human uterine leiomyoma. Fertility and Sterility; 95: 1805-8. 2011.

[20].Wang K, Guo DS, Zhang HQ, Li D, Zheng XL, Liu Y. Highly effective binding of viologens by p-sulfonatocalixarenes for the treatment of viologen poisoning. Journal of Medicinal Chemistry; 52: 6402-12. 2009.

[21].Li, D., Du, C. Y., Tang, X. J., Jin, Y. X., Lei, T., Yao, Y., Yang, Z., and Zhang, T., [Changes of heart rate variability and impairment of learning and memory induced by cerebral ichemia/reperfusion in rats.]. Sheng Li Xue Bao,. 59(1): p. 35-41. 2007.

[22].Li, D., Jin, Y. X., Yang, Z., and Zhang, T., Analysis of Multifibre Renal Sympathetic Nerve Recordings. Lecture Notes in Computer Science. 3973: p. 734 - 739. 2006.

[23].Li, D., Du, C. Y., Tang, X. J., Jin, Y. X., Lei, T., Yao, Y., Yang, Z., and Zhang, T., Effect on autonomic nervous system and learning and memory induced by cerebral ischemia/reperfusion in rats. Acta Biophsica Sinica, 2006. 22(supplement): p. 83.

[24].Yang, Z. Q., Li, Y. N., Chen, F., Li, D., Zhang, Z. F., Liu, Y. X., Zheng, D. X., Wang, Y., and Shen, G. F., Expression of hsTRAIL in Chlamydomonas reinhardtii Chloroplast. Chinese Science Bulletin 2006. 51(12): p. 1400-1405.

[25].Yuan, W. S., Zhao, Z. G., Li, D., and Li, J., [Biological characteristics and ability of supporting hematopoiesis of fetal bone marrow mesenchymal stem cells]. Shandong Medical Journal, 2005. 45(11): p. 31-32.

[26].Song, J. M., Xu, D., Fan, E. J., Xu, S. R., Li, D., and Zhao, C. H., [Cyclin D2 expression in chronic myelogenous leukemia]. Zhong hua Xue Ye Xue Za Zhi, 2004. 25(2): p. 103-5.

[27].Li, D., Yuan, W. S., Ma, X. T., Cai, H. G., Ming, Y., Li, J., and Zhao, R. C., High Density Fermentation and Purification of Recombinant Human IL-6/2 Fusion Protein. High Technology Letters, 2003. 45(11): p. 27-30.

[28].Deng, W. M., Li, C. H., Liao, L. M., Ge, W., Li, D., Yuan, W. S., Zhao, Z. G., You, S. G., Deng, H. Y., and Zhao, R. C., adult bone marrow-derived pluripotential mesenchymal stem cells give rise to skin cells and regenerate skin tissue. Chinese Journal of Cell Biology, 2003. 25(02): p. 98-105.

[29].Luo, S. Q., Zheng, D. X., Liu, Y. X., Li, D., Rao, Q., and Wu, K. f., Expression of srhM-CSFR in Insect Cells and Analysis of Binding Activity for its Ligand Chinese Journal of Biochemistry and Molecular Biology, 2000. 16(04): p. 443-447.

[30].Shao, Y., Xiao, S., Li, D., Liu, Y. X., Liu, S. L., and Zheng, D. X., Molecular clone of CD2 cytoplasmic binding protein in human lymphocyte. Acta Academiae Medicinae Sinicae, 1999. 21(02).

Projects

Projects

[1].1996 ~2000: National 863 program: soluble receptors for malignant tumor guided treatment of experimental research, participate, Research Assistant.

[2].2001 ~2003: the 863 program: IL6/IL2 fusion protein therapy for preclinical research in oncology, Main Participant

[3].2008 ~2010: the National Natural Science Foundation of China: the role of adenosine phosphate in the treatment of vascular smooth muscle and atherosclerosis, Main Participant.

[4].2008 -2011,the Natural Science Foundation of Tianjin: the study of the treatment of atherosclerosis with estrogen metabolites 2ME, Main Participant.

[5].2010 -2013, the Natural Science Foundation of Tianjin, the study of uterine leiomyoma, Co-PI.

[6].2010: the annual plan of overseas teacher project (Harvard University Professor Wang Dazhi) of Ministry of education, PI.

[7].2011 -2015:the Major State Basic Research Development Program of China (973 Program), sub topic: molecular mechanism of formation of renal glomerulus and podocytes development, Main Participant.

Teaching

Teaching

[1].Undergraduate: Biochemistry, for Clinical medical students and dental medical students

[2].Undergraduate: Biochemistry, for MBBS Students

[3].Master: Signal Transduction

[4].public course: Introduction to major diseases