Biography 

1. Research Areas

 Cancer biology;

 Oncogenes;

microRNA functions;

 Cancer genomics

2. Education

2006.9-2011.6, PhD in Biochemistry and Molecular biology, School of Medicine in Nankai University

2002.9-2006.6, Bachelor’s degree in Biotechnology, College of Life sciences in Nankai University

3. Professional Experience

2011.7- Present, Assistant Professor in School of Medicine, Nankai University

4. Awards

 2012.9, Awards for Science and Technology in Cancer Research from Chinese Anti-Cancer Association

Research & Achievements

Research Achievements

Peer-Reviewed Journal Papers

[1]Liu Y, Wang Z, Huang D, Wu C, Li H, Zhang X, Meng B, Li Z, Zhu T, Yang S*, Sun W*. LMO2 promotes tumor cell invasion and metastasis in basal-type breast cancer by altering actin cytoskeleton remodeling. Oncotarget. 2016 Nov 17. doi: 10.18632/oncotarget.13434.

[2]Liu Y, Huang D, Wang Z, Wu C, Zhang Z, Wang D, Li Z, Zhu T, Yang S, Sun W*. LMO2 attenuates tumor growth by targeting the Wnt signaling pathway in breast and colorectal cancer. Sci Rep. 2016 Oct 25;6:36050. doi: 10.1038/srep36050.

[3]Wu C, Liu Y, Gu X, Zhu T, Yang S*, Sun W*. LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1442-8.

[4]Liu L, Tong Q, Liu S, Cui J, Zhang Q, Sun W*, Yang S*. ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer. PLoS One. 2016; 16;11(2):e0148774.

[5]Hu F, Wang C, Guo S, Sun W, Mi D, Gao Y, Zhang J, Zhu T, Yang S. δEF1 promotes osteolytic metastasis of MDA-MB-231 breast cancer cells by regulating MMP-1 expression. Biochim Biophys Acta. 2011 Mar;1809(3):200-10.

[6]Hu F, Wang C, Du J, Sun W, Yan J, Mi D, Zhang J, Qiao Y, Zhu T, Yang S. DeltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression. Biochim Biophys Acta. 2010 Feb;1802(2):301-12.

[7]Sun W, Shen W, Yang S, Hu F, Li H, Zhu TH. miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β. Cell Res. 2010;20(10):1158-69.

[8]Sun W, Shen WW, Yang S, Hu F, Gao Y, Qiao YH, Zhu TH. Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic cells. J Biomed Sci. 2010;17(1):22.

[9]Sun W, Yang S, Shen W, Li H, Gao Y, Zhu TH. Identification of DeltaEF1 as a novel target that negatively regulated by LMO2 in T cell leukemia. Eur J Haematol. 2010; 85(6): 508-519.

Projects

Projects

[1]2014.1-2016.12, National Natural Science Fund of China Youth Program 

[2]2014.4-2017.4, Tianjin Natural Science Fund Program

[3]2013.1-2015.12, Youth Program of the Ministry of Education of China

Teaching

Teaching

[1]Undergraduate: Principles of Medical Genetics

                Medical Molecular Genetics

Experiment of Medical Molecular Genetics