Biography

1. Research Interest

Molecular mechanism of tumor metastasis

2. Educational Background

(1) School of Medicine, Tianjin Medical University, Tianjin, China, M.D. 1992-1997, Medicine

(2) Department of Pathology, Tianjin Medical University, Tianjin, China, MS 2000-2003, Pathology

(3) Department of Pathology, Tianjin Medical University, Tianjin, China, Ph.D. 2005-2008, Oncology

(4) Department of Pathology, the University of Texas M. D. Anderson Cancer Center, U.S.A. Visiting associate professor. 2010-2011

(5) Pathology,Department of Pathology, M.D.Anderson cancer center. U.S.A. Post-doctoral fellow. 2011-2013

3.Work Experience

(1) Lecturer, Department of Pathology, Medical College of the Armed Police Forces, Tianjin, China, 1997-2005

(2) Graduate Research Assistant, Department of Pathology, Tianjin Medical University, Tianjin, China, 2005-2007

(3) Assistant Professor, Department of Pathology, Tianjin Medical University, Tianjin, China, 2007-2013

(4) Professor, Department of Pathology, Tianjin Union Medical Center, Tianjin, China, 2013-present

4. Awards

(1)The First Prize for Science and Technology Progress Award of Tianjin, Tianjin, China, 2006JB-1-007-R3 (rank 3)

(2)The third prize for Science and Nature Award of Tianjin, Tianjin, China, 2004ZR-3-011-R3 (rank 3)

(3) The Third Prize for Science and Technology Progress Award of Tianjin, Tianjin, China, 2016JB-3-084 (rank 1)

5. Social Service

(1) Member of the standing committee, Tianjin Pathologist Association.

(2) Vice-chairmen, Tianjin pathology quality control center.

(3) Committee member, The first Tianjin Medical Association Clinical precision medical Specialized Committee.

(4) Committee member, The ninth Tianjin branch of Chinese Medical Association.

(5)Member of the standing committee, Beijing Cancer Society pathology Association.

Achievements

Patent, Stem cell spheres induced culture medium and method, ZL201310286095.3201703, (rank 1).

Peer-Reviewed Journal Papers

1.Gao Y, Sun W, Shang W, Li Y, Zhang D, Wang T, Zhang X, Zhang S, Zhang Y, Yang R.Lnc-C/EBPβ Negatively Regulates the Suppressive Function of Myeloid-derived Suppressor Cells. Cancer Immunol Res. 2018 Aug 31. pii: canimm.0108.2018. doi: 10.1158/2326-6066.CIR-18-0108. [Epub ahead of print]

2.Liu G, Wang Y, Fei F, Wang X, Li C, Liu K, Du J, Cao Y, Zhang S. Clinical characteristics and preliminary morphological observation of 47 cases of primary anorectal malignant melanomas. Melanoma research. 2018

3.Liu G, Fei F, Qu J, Wang X, Zhao Y, Li Y, Zhang S. iTRAQ-based proteomic analysis of DMH-induced colorectal cancer in mice reveals the expressions of β-catenin, decorin, septin-7, and S100A10 expression in 53 cases of human hereditary polyposis colorectal cancer. Clinical translational oncology. 2018 Jun 28. doi: 10.1007/s12094-018-1912-6.

4.Li Y, Cong J, Fei F, Zhang Z, Yu Y, Xu C, Zhang S. The use of high-resolution colonic manometry to establish etiology and direct treatment in patients with constipation: case series with correlation to histology. J Gastroenterol Hepatol. 33 (2018) 1864–1872.

5.Zhang S, Fei F, Wang H, Gu Y, Li C, Wang X, Zhao Y, Li Y. Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer. Cancer Science. 2018;109:1825–1833.

6.Wang Y, Zhang S, Xu T, Zhang T, Mo Y, Liu J, Yan L, Xing F. Ultra-sensitive and ultra-fast detection of whole unlabeled livingcancer cell responses to paclitaxel with a graphene-based biosensor. Sensors and Actuators B: Chemical. 2018; 417–425

7.Wang X, Fei F, Qu J, Li C, Li Y, Zhang S. The role of septin 7 in physiology and pathological disease: A systematic review of current status. J Cell Mol Med. 2018;22:3298–3307.

8.Yang Z, Yao H, Fei F, Li Y, Qu J, Li C, Zhang S. Generation of Erythroid Cells from Polyploid Giant Cancer Cells: Re-Thinking about Tumor Blood Supply. Journal of Cancer Research and Clinical Oncology, 144(4), 617-627.

9.Fei Fei, Jie Qu, Chunyuan Li, Xinlu Wang, Yuwei Li and Shiwu Zhang. Role of metastasis-induced protein S100A4 in human non-tumor pathophysiologies. Cell & Bioscience2017;7:64

10.Zhong X, Wang X, Fei F, Zhang M, Ding P, Zhang S.The Molecular Mechanism and Neuroprotective Effect of Dihydrocapsaicin-Induced Mild Hypothermia After Cardiopulmonary Resuscitation in Rats. Ther Hypothermia Temp Manag. Ther Hypothermia Temp Manag. 2018 Jun;8(2):76-82.

11.Li Y, Yu Y, Li S, Zhang M, Zhang Z, Shi Y, Zhang X, Zhang S. iTRAQ-based proteomic analysis reveals the roles of progesterone receptor, inflammatory and fibrosis for slow transit constipation. Journal of Gastroenterology and Hepatology. 2018 Feb;33(2):385-392.

12.Fei F, Jie Qu, Mingqing Zhang, Chunyun Li, Yuwei Li, Shiwu Zhang. S100A4 in cancer progression and metastasis: A systematic review. Oncotarget, 2017,1-20, 2017, Vol. 8, (No. 42), pp: 73219-73239

13.Zhang D, Fei F, Li S, Zhao Y, Yang Z, Qu J, Zhang X, Yin Y, Zhang S. The role of β-catenin in the initiation and metastasis of TA2 mice spontaneous breast cancer. Journal of Cancer. 2017; 8(11): 2114-2123.

14.Wang Y, Zhang C, Zhang S, Zhao Z, Wang J, Song J, Wang Y, Liu J, Hou S. (2017). Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation. Sci Rep. 2017 Apr 28;7(1):1280. doi: 10.1038/s41598-017-01480-2.

15.Tang T, Yang Z, Zhang D, Qu J, Liu G, Zhang S. Clinicopathological study of 9 cases of prostate cancer involving the rectal wall. Diagnostic Pathology. 2017 Jan 17;12(1):8.

16.Zhang D, Yang X, Yang Z, Fei F, Li S, Qu J, Zhang M, Li Y, Zhang X, Zhang S. Daughter Cells and Erythroid Cells Budding from PGCCs and Their Clinicopathological Significances in Colorectal Cancer. J Cancer 2017; 8(3):469-478. doi:10.7150/jca.17012.

17.Zhang S, Zhang D, Yang Z, Zhang X. Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects. Stem Cells Int. 2016;4810734. Epub 2016 Oct 23.

18.Wang Y, Zhang S, Zhang C, Zhao Z, Zheng X, Xue L, Liu J, Yuan XC. Investigation of an SPR biosensor for determining the influence of connexin 43 expression on the cytotoxicity of cisplatin. Analyst. 2016 May 23;141(11):3411-20

19.Zhang S, Mercado-Uribe I, Sood A, Bast R and Liu J. Coevolution of neoplastic epithelial cells and multilineage stroma via polyploid giant cells during immortalization and transformation of mullerian epithelial cells. Genes & Cancer, 2016 Mar; 7(3-4): 60–72.

20.Yang Y, Liu J, Song F, Zhang S. The clinical diagnostic value of target biopsy using narrow-band imaging endoscopy and accurate laryngeal carcinoma pathologic specimen acquisition. Clin Otolaryngol. Clin Otolaryngol. 2017 Feb;42(1):38-45.

21.Wang Y, Zhang Y, Zhang S, Zhao Z, Min C, Liu J, Yuan X. An optical detection method for analyzing the cellular response to paclitaxel at the single cell level. Anal Methods, 2016, DOI: 10.1039/C6AY00017G

22.Fei F, Zhang D, Yang Z, Wang S, Wang X, Wu Z, Wu Q* and Zhang S. The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer. Journal of Experimental & Clinical Cancer Research. 2015 Dec 24;34(1):158. doi: 10.1186/s13046-015-0277-8.

23.Liu G, Wang H, Yang Z, Tang T, Zhang S. Is It a Metastatic Disease: A Case Report and New Understanding of Rosai-Dorfman Disease? American Journal of Dermatopathology. 2016;38(6):e72-6.

24.Zhang S, Yang C, Yang Z, Zhang D, Ma X, Mills G, Liu Z. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res 2015; 5(4):1265-1280.

25.Zhang S, Xu X, Zhu S, Liu J. PGCCs Generating Erythrocytes to Form VM Structure Contributes to Tumor Blood Supply. BioMed Research International.2015, ID 402619.

26.Lv H, Shi Y, Zhang L, Zhang D, Liu G, Yang Z, Li Y, Fei F, Zhang S: Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor. BMC Cancer 2014, 14(1):576.

27.Zhang D, Wang Y, Zhang S. Asymmetric cell division in polyploid giant cancer cells and low eukaryotic cells. BioMed Research International.2014, ID 432652.

28.Zhang L, Ding P, Lv H, Zhang D, Liu G, Yang Z, Li Y, Liu J, Zhang S. Number of polyploid giant cancer cells and expression of EZH2 are associated with VM formation and tumor grade in human ovarian tumor. BioMed Research International.2014, ID 903542.

29.Wang W, Lin P, Sun B, Zhang S, Cai W, Han C, Li L, Lu H, Zhao X. Epithelial-Mesenchymal Transition Regulated by EphA2 Contributes to Vasculogenic Mimicry Formation of Head and Neck Squamous Cell Carcinoma. BioMed Research International. 2014;ID:803914

30.Zhang S, Mercado-Uribe I, Hanash S, Liu J. iTRAQ-based proteomic analysis of distinct protein expression patterns in ovarian polyploid giant cancer cells and their budding daughter cells. Plos one.2013;8(11):e80120.

31.Ren L, Wang X, Dong Z, Liu J, Zhang S. Bone metastasis from breast cancer involves elevated IL-11 expression and the gp130/STAT3 pathway. Med Oncol. 2013; 30:634. DOI 10.1007/s12032-013-0634-4

32.Zhang S, Mercado-Uribe I, Liu J. Tumor stroma and differentiated Cells can be Originated directly from Polyploid Giant Cancer Cells Induced by Paclitaxel. Int J Cancer. 2013 Feb 1;134(3):508-18.

33.Zhang S, Mercado-Uribe I, Sun B, Kuang J, Liu J*. Generation of Cancer Stem-like cells through formation of polyploidy giant cancer cells. Oncogene. 2014;33(1):116-28.

34.Zhang S, Mercado-Uribe I, Liu J*. Generation of erythroid cells by normal and cancer cells in vitro and in vivo. Cancer lett. 2013; 333(2):205-12.

Projects

(1)National Science Foundation of China. The molecular mechanism of c-Myc-Gcn5-HDAC2 regulating PGCCs generating erythrocytes and its maturation. 81672426, 201701-202012, RMB 570,000. (PI)

(2) National Science Foundation of China. The molecular mechanism of polyploid giant cancer cells with stem cell properties induced by hypoxia and asymmetric division. 81472729, 201501-201812, RMB 720,000. (PI)

(3) Technological Special Project of Tianjin. Early diagnosis and prevention of postoperative patients with colorectal cancer. 17ZXMFSY00120, 201710-202009, RMB 200,000. (PI)