Biography

1. Research Interest

(1) National Natural Science Foundation of China, 81571054, Medical screening and compatibility strategy for MCI rats based on the homeostasis of Bip-GABAA receptor α1 protein, 2016-1~ 2019-12, In research, Study Director.

(2) National Natural Science Foundation of China, 81100984, “The mechanism of converting of KCC2-GABA A receptor in the protective effect on brain of propofol post-conditioning ”, 2012-1~2014-12, Finished, Study Director.

(3) National Natural Science Foundation of China, 81071059, “The mechanism of PI3K-AMPA Receptor GluR2 trafficking in long-term brain protection of propofol post-conditioning”, 2011-1~ 2013-12,Finished，Project leader.

(4) National Natural Science Foundation of China, 81371245, NMDA receptor NR2B-PN-(-) IRE DMT1 pathway in the regulation ofremifentanil induced hyperalgesia and the therapeutic role of H2, January 2014-1~ 2017-12, Finished, the second leader .

(5)National Natural Science Foundation of China, 30972847, “The mechanism of δ-opioid receptor-GSK-3-NMDA receptor trafficking in the regulation of remifentanil induced hyperalgesia”, January 2010-1~2012-12, Finished, the third leader .

(6)Tianjin Research Program of Application Foundation and Advanced Technology (General Program) 15JCYBJC25600, “Effects of Propofol on Glioma Invasiveness and Regulation of ADAR2-CPARs-Xc Reverse Transporter”, 2015-4~2018-3, In research, Study Director.

(7)Tianjin Municipal Planning Commission Science and Technology Project,15KG117, “The compatibility strategy of anesthetics in perioperative period of MCI patients—from basic research to clinical practice ”, 2015-10~2018-10, In research, Study Director.

(8)Tianjin Important Science Support Project, 12ZCZDSY03000, “The mechanism of POCD induced by Sevoflurane and appropriate depth of the elderly”, 2012-4~2015-3, finished, the second leader .

(9)Tianjin Health Bureau Science and Technology Fund, 09KZ106, The mechanism of sevoflurane on the synaptic plasticity of rats with traumatic brain, 2009-4~2011-3, finished, Study Director.

(10)Tianjin Medical University Science Fund, 2006ky39, The protective effects of propofol and midazolam on myocardial ischemia in rats, 2006-9~2008-9,Finished, Study Director.

2. Educational Background

2011-05~2012-05:Visiting Scholar,Anesthesiology,Harvard Medical School, USA,

2007-09~2010/07:Ph.D,Tutor:Professor Wang Guolin, Anesthesiology, Tianjin Medical University

2000-09~2003-07:Master, Tutor: Professor Wang Guolin, Anesthesiology,Tianjin Medical University

1993-09~1998-07:Bachelor,Anesthesiology, Tianjin Medical University

3. Work Experience

2018-02~: Doctoral Supervisor, Surgery, Nankai University

2018-02~: Vice-President, Tianjin Third Central Hospital，

2015-07~:Chief Physician,Director of Anesthesiology, Tianjin Third Central Hospital 2015-01~:Doctoral Supervisor, Anesthesiology, Tianjin Medical University

2013-09~2015-07:Chief Physician, Department of Anesthesiology, General Hospital of Tianjin Medical University

2011-05~2012-05:Visiting Scholar, Anesthesiology, Harvard Medical School, USA,

2011-03~:Master Instructor, Anesthesiology, Tianjin Medical University

2009-09~2013-09:Deputy Chief Physician, Department of Anesthesiology, General Hospital of Tianjin Medical University

2005-05~2009-09:Attending Physician, Department of Anesthesiology, General Hospital of Tianjin Medical University

2004-08~2005-05:Visiting Scholar,Department of Anesthesiology, Singapore Central Hospital

1998-08~2005-05:Resident, Department of Anesthesiology, Tianjin Huanhu Hospital

4. Awards

(1)Wang Haiyun (1/5), The protective effect of propofol on post-cardiac ischemia-reperfusion injury, Tianjin Municipal Party Committee Organization Department, Tianjin Personnel Bureau, Tianjin Science Association, 2011 Tianjin Science and Technology Progress Award Third-class, 2011. (Wang Haiyun, Wang Guolin, Yu Yonghao, Wang Ying, Wang Zhiyong) (Annex 6)

(2)Wang Haiyun (4/7), The mechanism of ketamine and new methods of clinical application,Tianjin Municipal Party Committee Organization Department, Tianjin Personnel Bureau, Tianjin Science Association, 2004 Tianjin Science and Technology Progress Award, Second Class, 2004. (Wang Guolin, Yu Yonghao, Xie Hong, Wang Haiyun, Ren Shuqin, Cui Wei, Chen Hong) (Annex 7)

5. Social Service

(1)Deputy Director, Tianjin Institute of Anesthesiology

(2)Deputy Director,Chinese Medical Association Anesthesiologists Branch Youth Committee

(3)review expert,National Natural Science Foundation Committee

(4)Youth Committee,Chinese Medical Association Anesthesia Branch

(5)Standing Committee, Chinese Cardiothoracic Anesthesiology Pain Society

(6)Secretary, Department of Neurosurgery, Anesthesiology, Chinese Medical Association

(7)Committee, Chinese Research Hospital Association Anesthesia Branch

(8)Standing Committee, Tianjin Medical Association Anesthesiology Branch

(9)Standing Committee,Tianjin Cancer Anesthesia and Analgesia Professional Committee

(10)Committee and secretary, Tianjin Quality Control Center

(11)Cmmittee, Tianjin Medical Association Anesthesiologist Branch

(12)Editorial Panel,Chinese Journal of Anesthesiology

Achievements

Peer-Reviewed Journal Papers

1.Guo D, Li Y, Wang HY(* 通讯作者), Wang X, Hua W, Tang Q, Miao L, Wang G. Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery. Int J Neurosci. 2018, 6: 1-25.

2.Yang CY, Liu SY, Wang HY(* 通讯作者), Li YL, Guo D, Wang XY, Hua W, Wang GL. Neuroprotection by Propofol Post-Conditioning: Focus on PKMζ/KCC2 Pathway Activity. Cell Mol Neurobiol. 2017, 38(5):1-11.

3.Wang XY, Li YL, Wang HY(* 通讯作者), Zhu M, Guo D, Wang GL, Gao YT, Yang Z, Li T, Yang CY, Chen YM. Propofol inhibits invasion and proliferation of C6 glioma cells by regulating the Ca(2+) permeable AMPA receptor-system x(c)(-) pathway. Toxicol In Vitro. 2017,44:57-65.

4.Pajiyar AK, Wen Z, Wang H(* 通讯作者), Ma L, Miao L, Wang G. Comparisons of clinical performance of Guardian laryngeal mask with laryngeal mask airway ProSeal. BMC Anesthesiol. 2015,15:69.

5.Zhu M, Wang H(* 通讯作者), Zhu A, Niu K, Wang G. Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. PLoS One. 2015, 10(4):e0123728.

6.Wang H, Liu S, Wang H(* 通讯作者), Wang G, Zhu A. The effect of propofol postconditioning on the expression of K-Cl-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. Brain Res. 2015, 1597: 210-219.

7.Wang H, Dong Y, Zhang J, Xu Z, Wang G, Swain CA, Zhang Y, Xie Z. Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors. Br J Anaesth. 2014, 113(4):695-707.

8.Hu N, Wang C, Zheng Y, Ao J, Zhang C, Xie K, Li Y, Wang H, Yu Y, Wang G（*通讯作者）. The role of the Wnt/β-catenin-Annexin A1 pathway in the process of sevoflurane-induced cognitive dysfunction. J Neurochem. 2016, 137(2):240-252.

9.Hu N, Wang M, Xie K, Wang H, Wang C, Wang C, Wang C, Li Y, Yu Y, Wang G（*通讯作者）. Internalization of GluA2 and the underlying mechanisms of cognitive decline in aged rats following surgery and prolonged exposure to sevoflurane. Neurotoxicology. 2015,49:94-103.

10.Shu RC, Zhang LL, Wang CY, Li N, Wang HY, Xie KL, Yu YH, Wang GL(*通讯作者). Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats. Anesthesiology. 2015,122(4):908-920.

11.Li YZ, Tang XH, Wang CY, Hu N, Xie KL, Wang HY, Yu YH, Wang GL(*通讯作者). Glycogen synthase kinase-3β inhibition prevents remifentanil-induced postoperative hyperalgesia via regulating the expression and function of AMPA receptors. Anesth Analg. 2014, 119(4): 978-987.

12.Zhang L, Shu R, Wang H, Yu Y, Wang C, Yang M, Wang M, Wang G(*通讯作者). Hydrogen-rich saline prevents remifentanil-induced hyperalgesia and inhibits MnSOD nitration via regulation of NR2B-containing NMDA receptor in rats.，Neuroscience. 2014, 280: 171-180.

13.Zhang L, Shu R, Wang C, Wang H, Li N, Wang G(*通讯作者). Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull. 2014, 106: 47-55.

14.Joomye S, Yan D, Wang H, Zhou G, Wang G(*通讯作者). Consumption of Cisatracurium in different age groups, using a closed loop computer controlled system. BMC Anesthesiol. 2014, 14: 29.

15.Hu Nan, Guo D, Wang H, Xie K, Wang C, Li Y, Wang C, Wang C, Yu Y, Wang G(*通讯作者). Involvement of the blood-brain barrier opening in cognitive decline in aged rats following orthopedic surgery and high concentration of sevoflurane inhalation. Brain Res. 2014, 1551: 13-24.

16.Li Y, Wang H, Xie K, Wang C, Yang Z, Yu Y, Wang G(*通讯作者). Inhibition of Glycogen Synthase Kinase-3 beta Prevents Remifentanil-Induced Hyperalgesia via Regulating the Expression and Function of Spinal N-Methyl-D-Aspartate Receptors In Vivo and Vitro. Plos One. 2013, 8(10): e77790.

17.Wang H,Wang G(*通讯作者).Establishment and implementation of a neurosurgical anesthesiologist training system.The Journal of Clinical Anesthesiology.2017, 33(5): 421-424.

18.Chen Y,Wang H(*通讯作者), Wang H, Li P,Guo D,Li T.Effects of different ratios of medicine dosage for propofol and sevoflurane on postoperative cognitive function in elderly patients with mild cognitive impairment.Chin J Anesthesiol. 2017, 37(9): 1087-1090.

19.Chen Y, Wang H(*通讯作者), Wang H, Li P,Guo D,Li T. Appropriate compatibility of propofol and sevoflurane for posterior lumbar interbodyfusion of patients with mild cognitive impairment.The Journal of Clinical Anesthesiology.2017, 33(7): 637-641.

20.Tang Q, Xing J, Wang H(*通讯作者), Zhao J, Sun J. Median effective dose of etomidate inhibiting responses to endotracheal intubation when combined with dexmedetomidine in patients with obstructive jaundice. Chin J Anesthesiol.2017, 37(3): 341-343.

21.Guo D,Wang H(*通讯作者),Li T, Chen Y,Wang G. Effects of different ratios of medicine dosage for isoflurane and propofol on postoperative cognitive function of rats with mild cognitive impairment.Chin J Anesthesiol. 2016, 36(10): 1182-1186.

22.Zhu M,Liu S,Wang H(*通讯作者), Guo D, Wang X. Effect of propofol post-conditioning on oxygen-glucose deprivation and restoration-induced abnormal cell cycle activation in hippocampal neurons of rats. Chin J Anesthesiol. 2016, 36(9): 1048-1051.

23.Zhao Z,Wen Z,Wang H(*通讯作者), Zhang J,Xing J,Liu Y,Ye Z. Effect of PCV on mild obstructive ventilation dysfunction in elderly patients undergoing laparoscopic cholecystectomy .The Journal of Clinical Anesthesiology. 2016, 32(11): 1045-1048.

24.Wang X,Wang H(*通讯作者), Wang G,Yang Z,Zhang T. Effects of propofol on invasion and migration of glioma cells in rats and the role of ADAR2-AMPA receptor GluR2 pathway. Chin J Anesthesiol. 2016, 36(6): 712-715.

25.Liu S,Wang H,Wang G,Wang G,Wang H (*通讯作者). Effect of sub-anesthetic doses of isoflurane and propofol on postoperative cognition and underlying mechanism in rats with mild cognitive impairment. Chinese Medicine Magzine . 2016, 96(2): 142-146.

26.Liu S, Wang H (*通讯作者), Wang G, Wang H,Zhu M. Role of hippocampal PKM‘／KCC2 pathway in propofol postconditioning-induced long‘term cerebral protection following cerebral ischemia·reperfusion in rats . Chin J Anesthesiol. 2015, 35(9): 1054-1056.

27.Wang H, Wang H (*通讯作者), Wang G, Liu S, Zhu A.Effects of alcohol dependence on expression of spinal neuronal K+-Cl-cotransporter 2 in rats. Chin J Anesthesiol. 2015, 35(4): 466-469.

28.Wang B, Wang G, Chen J, Wang H(*通讯作者). Effect of propofol post-conditioning on expression of GluR1-containing AMPA receptors during cerebral ischemia-reperfusion injury in rats. Chin J Anesthesiol. 2015, 35(2): 204-207.

29.Zhu M, Fu W,Wang H(*通讯作者), Wang G. Effect of propofol post-conditioning on ADAR2-AMPA receptor GluR2 pathway in cerebral ischemia-reperfusion rats. The Journal of Clinical Anesthesiology. 2015, 31(7): 693-696.

30.Wang H, Wang H(*通讯作者), Wang G,Zhu A,Liu S. Effects of propofol post-conditioning on hippocampal neuronal K+-Cl-co-transporter 2 expression in rats with cerebral ischemia/reperfusion injury. Chin J Anesthesiol. 2014, 34(10): 1181-1184.

31.Zhu M,Wang H(*通讯作者), Fu W,Wang G, Su X,Wang Q.Effect of propofol post-conditioning on ADAR2-AMPA receptor GluR2 pathway in hippocampal neurons of fetal rats subjected to oxygen-glucose deprivation.Chin J Anesthesiol. 2014, 34(8): 1000-1003.

32.Zhu A,Wang H(*通讯作者), Wang G,Yang Z,Zhang T,Yang J.Effect of propofol post-conditioning on synaptic transmission in neurons in CA 1 region during oxygen-glucose deprivation and restoration in hippocampi in rats. Chin J Anesthesiol. 2014, 34(3): 325-327.

33.Wang C,Wang G,Wang H(*通讯作者), Wei Y. P13K-AMPA-GluR2 pathway in post-propofol treatment reduces cerebral ischemia-reperfusion injury in rats. Chin J Anesthesiol. 2013, 33(4): 485-489.

34.Wei Y,Wang G,Wang H(*通讯作者), Wang C. Effect of Akt-GSK3β pathway on post-long-term brain protection in rats with cerebral ischemia-reperfusion induced by propofol. Chin J Anesthesiol. 2013, 33(1): 91-94.

Projects (According to Research Interest)