Biography 

1. Research Areas

1) The molecular mechanism of mitochondrial protein translocation and its role in metabolic diseases;

2) Nanozyme mimetics and their applications in biomedicine

2. Education

2005-2010Ph.D. in Institute of Biophysics,

Chinese Academy of Sciences, Beijing

2000-2004B.S. in Beijing Institute of Technology

3. Awards

2014NHLBI Director’s Award, for work on the metabolic effect of germline TP53 mutations in Li-Fraumeni syndrome, NHLBI

2014Orloff Science Award, for contribution to the Li-Fraumeni syndrome clinical study, NHLBI, Division of Intramural Research

4. Peer-Reviewed Journal Papers

1)Huang, X*, Zhuang, J*, Chung, SW, Halpert, G, Negron, K, Huang, B, Hwang, PM, Hanes, J, Suk, JS. Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-associated Hypoxia. ACS Nano. 2019, 13: 236–247 (*Co-first author)

2) Wang, P, Li, J, Walcott, F, Kang, J, Starost, M, Talagala, SL, Zhuang J, Park, J, Huffstutler, R, Bryla, C, Mai, P, Pollak, M, Annunziat, C, Savage, S, Fojo, A, Hwang, PM. Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome.Journal of Clinical Investigation. 2017, 127: 132-136.

3) Zhuang, J, Kamp W, Li, J, Liu, C, Kang, J, Wang, P, Hwang, PM. FOXO3 and CHCHD4 regulate p53 nuclear activity in response to exercise.The Journal of Biological Chemistry. 2016, 291: 24819-24827.

4)Zhuang, J, Wang, P, Huang, X, Chen, X, Kang, J, Hwang, PM.Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A. 2013, 110: 17356-17361. (Recommended by Faculty of 1000)

5)Wang, P, Ma, W, Park, J, Celi, FS, Arena, R, Choi, JW, Ali, QA, Tripodi, DJ, Zhuang, J, Lago, CU, Strong, LC, Talagala, SL, Balaban, RS, Kang, J, Hwang, PM. Increased Oxidative Metabolism in the Li–Fraumeni Syndrome. New England Journal of Medicine. 2013, 368: 1027-1032.

6)Zhuang, J, Ma, W, Lago, CU, Hwang, PM. Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology? Free Radical Biology and Medicine. 2012, 53: 1279-1285.

7)Zhuang, J, Fan, K, Gao, L, Lu, D, Feng, J, Yang, D, Gu, N, Zhang, Y, Liang, M, Yan, X. Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using Their Intrinsic Peroxidase-Mimicking Activity. Molecular Pharmaceutics. 2012, 9: 1983-1989.

8)Jiang, T, Zhuang, J, Duan, H, Luo, Y, Zeng, Q, Fan, K, Yan, H, Lu, D, Ye, Z, Hao, J, Feng, J, Yang, D, Yan, X. CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis. Blood. 2012, 120: 2330-2339.

9)Zhuang, J, Jiang, T, Lu, D, Luo, Y, Zheng, C, Feng, J, Yang, D, Chen, C, Yan, X. NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radical Biology and Medicine. 2010, 49: 227-236.

10)Zhuang, J, Zhang, J, Gao, L, Zhang, Y, Gu, N, Feng, J, Yang, D, Yan, X. A novel application of iron oxide nanoparticles for detection of hydrogen peroxide in acid rain. Materials Letters. 2008, 62: 3972-3974.

11)Wang, L, Li, P, Zhuang J, Bai, F, Feng, J, Yan, X, Li, Y. Carboxylic acid enriched nanospheres of semiconductor nanorods for cell imaging. Angew Chem Int Ed Engl. 2008, 47: 1054-1057.

12)Gao, L*, Zhuang, J*, Nie, L, Zhang, J, Zhang Y, Gu, N, Wang, T, Feng, J, Yang, D, Perrett, S, Yan, X. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnology. 2007, 2: 577-583. (*Co-first author, highly cited paper)