I. Biography

1. Education

·         2003-2008,

Ph.D. Candidate in Biochemistry and Molecular Biology

College of Life Sciences, Wuhan University, China

·         1999-2003,

Bachelor of Applied Chemistry

College of chemistry and molecular sciences, Wuhan University, China

2. Professional Experience

·         Since 2017,

Associate professor in School of Medicine, Nankai University, China

·         2014-2017,

Postdoctoral research fellow in department of Chemistry, University of Duisburg-Essen, Germany

·         2010- 2013,

Postdoctoral research fellow in department of Microbiology, University of Osnabrück, Germany

·         2008- 2010,

Postdoctoral research fellow in Moe Key laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, China

II. Research & Achievements

1. Research Areas

Surface-enhanced Raman scattering (SERS) probes for cancer diagnosis, fabrication of theranostic probes

2. Selected Peer-reviewed Publications:

1)        Xiaojie Wang, Xinxin Yuan, Kexin Fu, Chang Liu, Lu Bai, Xinchao Wang, Xiaoyue Tan, Yuying Zhang. Colorimetric analysis of extracellular vesicle surface proteins based on controlled growth of Au aptasensors. Analyst, 2020, 146(6): 2019-2028.

2)        Kexin Fu, Xiaojie Wang, Xinxin Yuan, Dekun Wang, Xue Mi, Xiaoyue Tan, Yuying Zhang. Size-Dependent Penetration of Gold Nanoprobes into Fixed Cells. ACS Omega. 2020, 6(5): 3791-3799.

3)        Lu Bai, Xiaojie Wang, Kaifu Zhang, Xiaoyue Tan, Yuying Zhang, Wei Xie. Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells. Chemical Communications. 2019, 55: 12996-9.

4)        Yuying Zhang, Xue Mi, Xiaoyue Tan, Rong Xiang. Recent progress on liquid biopsy analysis using surface-enhanced Raman spectroscopy. Theranostics.2019, 9: 491-525.

5)        Yuying Zhang, Xin-ping Wang, Sven Perner, Agnes Bankfalvi, SebastianSchlücker,Effect of antigen retrieval methods on non-specific binding ofanti-body-metal nanoparticle conjugates on FFPE tissue, Analytical Chemistry,2018, 90(10): 760-8.

6)        Yuying Zhang, Bernd Walkenfort, Jun Hee Yoon, Sebastian Schlücker, Wei Xie. Gold and silver nanoparticle monomers are not SERS-active: a negative experimental study with silica-encapsulated, Raman-reporter-coated metal colloids. Physical Chemistry Chemical Physics, 2015, 17, 21120-6.

7)        Yuying Zhang, Viktoria Krieger, Michael Hensel. Application of Fluorescent Nanoparticles to Study Remodeling of the Endo-lysosomal System by Intracellular Bacteria. Journal of Visualized Experiments, 2015, (95), e52058, doi:10.3791/52058.

8)        Yuying Zhang, Michael Hensel. Evaluation of nanoparticles as endocytic tracers in cellular microbiology. Nanoscale, 2013, 5, 9296-309.

9)        Yuying Zhang, Ling Hu, Dahai Yu, Changyou Gao. Influences of silica particles internalization on adhesion and migration of human dermal fibroblasts. Biomaterials, 2010, 31(32), 8465-74.

3. Books and Chapters:

Yuying Zhang, Sebastian Schlücker; iSERS microscopy for tissue-based cancer diagnostics, Confocal Raman Microscopy, Springer, 01/2018: pages 347-379; ISBN: 978-3-319-75378-2, DOI:10.1007/978-3-319-75380-5_15.

III. Projects

·         01/2019-12/2022, National Natural Science Foundation of China: SERS imaging and analysis of nanocarrier accumulation and transcytosis into murine breast tumors enhanced by iRGD,.Role: PI.

·         01/2010-12/2012, National Natural Science Foundation of China: Fabrication and mechanism of a new type of microcapsule for the treatment of cancer by combining photodydamic and photohyperthermic therapy. Role: PI.

·         01/2010-12/2013, National Natural Science Foundation of China: Study of gradient medical polymer materials for regulating cell migration and differentiation. Role: Participant.

·         01/2011-12/2013, National Natural Science Foundation of China: The study of hydrogels with elastic pattern to modulate the spatial diffentiation of stem cells. Role: Participant.

IV. Teaching

·         Undergraduate: Chemistry inside the Human body