Research Focus

1.    Visualizing the infection behaviors of viruses and dissecting the virus-host dynamic interactions to reveal the viral infection mechanisms by single-virus tracking.

2.    The bioapplication of quantum dots (QDs), e.g. virus labeling and tracking with QDs, in-vivo imaging with QDs.

Education

2013 Ph.D. College of Chemistry and Molecular Science, Wuhan University, Analytical Chemistry

2001-2008 B.S. & M.S. College of Chemistry, Zhengzhou University, Applied Chemistry

Professional Experience

2019-present Associate Professor, School of Medicine, Nankai University

2017-2018, Associate Professor, Faculty of Materials Science and Chemistry, China University of Geosciences

2014-2017, Post Doctor, Department of Chemistry, University of Illinois at Chicago

Selected Publications (*corresponding author, ^#first author)

[1] Zhang, Y. P.^#; Wang, H. P.; Dong, R. L.; Li, S. Y.; Wang, Z. G.*; Liu, S. L.*; Pang, D. W. Proximity-Induced Exponential Amplification Reaction Triggered by Proteins and Small Molecules. Chem. Commun., 2021, 57(38): 4714-4717.

[2] Wang, Z. G.^#; Wang, L.^#; Lamb, D. C.; Chen, H. J.; Hu, Y.; Wang, H. P.; Pang, D. W.*; Liu, S. L.* Real-Time Dissecting the Dynamics of Drug Transportation in the Live Brain. Nano Lett., 2021, 21 (1), 642−650.

[3] Wang, Z. G.^#; Liu, S. L.^#; Pang, D. W.*Quantum Dots: A Promising Fluorescent Label for Probing Virus Trafficking. Acc. Chem. Res., 2021, 54(14): 2991-3002.

[4] Wang, H. P.^#; Wang, Z. G.*; Liu, S. L.* Current Status and Future Trends of Vaccine Development Against Viral Infection and Disease. New J. Chem., 2021, 45(17): 7437-7449.

[5]Liu, H. Y. ^#; Wang, Z. G. ^#; Hu, Y.; Shi, X. H.; Chen, H. J.; Li, X.; Liu, S. L.; Pang, D. W.* In-Situ Quantitation of Genome Release of Japanese Encephalitis Viruses by Quantum Dot-Based Single-Virus Tracking. Nano Today, 2021, 40, 101271.

[6]Chen, H. J.^#; Hu, Y.; Yao, P.; Ning, D.; Zhang, Y. P.; Wang, Z. G.*; Liu, S. L.*; Pang, D. W. Accurate and Efficient Lipoprotein Detection Based on the HCR–DNAzyme Platform. Anal. Chem., 2021, 93(15), 6128-6134.

[7]Shi, X. H.^#; Dai, Y. Y.; Wang, L.; Wang, Z. G.*; Liu, S. L.* Water-Soluble High-Quality Ag₂Te Quantum Dots Prepared by Mutual Adaptation of Synthesis and Surface Modification for In Vivo Imaging. ACS Appl. Bio Mater.,2021, 4, 10, 7692–7700.

[8]Wang, L.^#; Shi, X. H.; Zhang, Y. F.; Liu, A. A.; Liu, S. L.; Wang, Z. G.*; Pang, D. W. CdZnSeS Quantum Dots Condensed with Ordered Mesoporous Carbon for High-Sensitive Electrochemiluminescence Detection of Hydrogen Peroxide in Live Cells. Electrochim. Acta, 2020, 362, 137107.

[9]Liu, S. L.^#; Wang, Z. G.^#; Xie, H. Y.; Liu, A. A.; Lamb, D. C.; Pang, D. W.* Single-Virus Tracking: From Imaging Methodologies to Virological Applications. Chem. Rev., 2020, 120(3), 1936-1979.

[10]Liu, H.^#; Wang, Z. G.; Liu, S. L.; Yao, X.; Chen, Y.; Shen, S.; Wu, Y.; Tian, W.* Intracellular Pathway of Halloysite Nanotubes: Potential Application for Antitumor Drug Delivery. J. Mater. Sci., 2019, 54(1), 693-704.

[11] Liu, S. L.^#; Wang, Z. G.^#; Hu, Y.; Xin, Y.; Singaram, I.; Gorai, S.; Zhou, X.; Shim, Y.; Min, J. H.; Gong, L. W.; Hay, N.; Zhang, J.; Cho, W.* Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. Mol. Cell, 2018, 71(6),1092-1104.

[12]Wang, Z. G.^#; Liu, S. L.; Cho, W.* Orthogonal Lipid Sensors Determine Differential Signaling Roles of PtdIns (3, 4, 5) P₃ and PtdIns (3, 4) P₂. FASEB J., 2017, 31, 946-7.

[13]Wang, Z. G.^#; Liu, S. L.^#; Hu, Y. J.; Tian, Z. Q.; Hu, B.; Zhang, Z. L.; Pang, D. W.* Dissecting the Factors Affecting the Fluorescence Stability of Quantum Dots in Live Cells. ACS Appl. Mater. Inter., 2016, 8(13), 8401-8408.

[14] Park, M. J.^#; Sheng, R.^#; Silkov, A.; Jung, D. J.; Wang, Z. G.; Xin, Y.;Kim, H.; Thiagarajan-Rosenkranz, P.; Song, S.; Yoon, Y.; Nam, W.; Kim, I.; Kim, E.; Lee, D. G.; Chen, Y.; Singaram, I.; Wang, L.; Jang, M. H.; Hwang, C. S.; Honig, B.; Ryu, S.; Lorieau, J.; Kim, Y. M.; Cho, W.* SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins. Mol. Cell, 2016, 62(1), 7-20.

[15]Liu, S. L.^#; Wang, Z. G.^#; Zhang, Z. L.; Pang, D. W.*Tracking Single Viruses Infecting Their Host Cells Using Quantum Dots. Chem. Soc. Rev., 2016, 45(5), 1211-1224.

[16] Wang, Z. G.^#; Liu, S. L.; Zhang, Z. L.; Tian, Z. Q.; Tang, H. W.; Pang, D. W.* Exploring Sialic Acid Receptors‐Related Infection Behavior of Avian Influenza Virus in Human Bronchial Epithelial Cells by Single‐Particle Tracking. Small, 2014, 10(13), 2712-2720.

[17]Liu, S. L.^#; Zhang, L. J.^#; Wang, Z. G.; Zhang, Z. L.; Wu, Q. M.; Sun, E. Z.; Shi, Y. B.; Pang, D. W.*Globally Visualizing the Microtubule-Dependent Transport Behaviors of Influenza Virus in Live Cells. Anal. Chem., 2014, 86(8), 3902-3908.

[18]Liu, S. L.^#; Wu, Q. M. ^#; Zhang, L. J.; Wang, Z. G.; Sun, E. Z.; Zhang, Z. L.; Pang, D. W.*Three‐Dimensional Tracking of Rab5‐and Rab7‐Associated Infection Process of Influenza Virus. Small, 2014, 10(22), 4746-4753.

[19]Liu, S. L.^#; Li, J.^#; Zhang, Z. L.; Wang, Z. G.; Tian, Z. Q.; Wang, G. P.; Pang, D. W.* Fast and High-Accuracy Localization for Three-Dimensional Single-Particle Tracking. Sci. Rep., 2013, 3(1), 1-5.

[20]Wang, Z. G.^#; Liu, S. L.; Tian, Z. Q.; Zhang, Z. L.; Tang, H. W.; Pang, D. W.* Myosin-Driven Intercellular Transportation of Wheat Germ Agglutinin Mediated by Membrane Nanotubes Between Human Lung Cancer Cells. ACS Nano, 2012, 6(11), 10033-10041.

Projects

1.    National Natural Science Foundation of China (21977054), Revealing the molecular mechanisms of influenza virus-regulated PI3K/Akt signaling pathway by single particle tracking, 2020-2023. Role: PI.

2.    National Key Research and Development Program of China (2019YFA0210500), 2019-2023. Role: Participant.

3.    National Natural Science Foundation of China (91953107), 2020-2022. Role: Participant.

4.    Sino-German Scientist Cooperation and Exchanges (M-0309), 2020-2022. Role: Participant.

Teaching

Nanobiological Analytical Chemistry