Rearch Focus

The regulatory mechanism of kidney disease.

Education

Ph.D., Nankai University, Biochemistry and Molecular Biology, 2019

M.S., Nankai University, Genetics, 2011

B.S., Shandong University, Biotechnology, 2008

Professional Experience

2019-present, Lecturer, School of Medicine, Nankai University

2011-2015, Technician, School of Medicine, Nankai University

Selected Publications

[1] Dekun Wang, Min Xiong, Chuan’ai Chen, Lingfang Du, Ze Liu, Yuzhi Shi, Mianzhi Zhang, Junbo Gong, Xianrong Song, Rong Xiang, Ergang Liu, and Xiaoyue Tan*, Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy. Kidney International, 2018, 94(1): 91-101.

[2] Dekun Wang^#, Qingwen Meng^#, Lihong Huo, Meng Yang, Lingling Wang, Xinyu Chen, Jianchao Wang, Zhiguo Li, Xiaoying Ye, Na Liu, Qiuyan Li, Zhen Dai, Hongsheng Ouyang, Ning Li, Jun Zhou*, Lingyi Chen*, and Lin Liu*, Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein & Cell, 2015. 6(2): p. 152-6.

[3] Chuan’ai Chen, Dekun Wang, Yangyan Yu, Tianyuan Zhao, Ningning Min, Yan Wu, Lichun Kang, Yong Zhao, Lingfang Du, Mianzhi Zhang, Junbo Gong, Zhujun Zhang, Xue Mi, Shijing Yue and Xiaoyue Tan*, Legumian promotes tubular feeroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death & Disease, 2021. 12:65.

[4] Long Shen^#., Lichun Kang^#, Dekun Wang, Jing Xun, Chuan’ai Chen, Lingfang Du, Mianzhi Zhang, Junbo Gong, Xue Mi, Shijing Yue, Yuying Zhang, Xiangrong Song, Rong Xiang, Zhujun Zhang*, and Xiaoyue Tan*, Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation. Cancer Letters, 2020. 472: p. 40-49.

[5] Lichun Kang, Long Shen, Liqing Lu, Dekun Wang, Yong Zhao, Chuan’ai Chen, Lingfang Du, Junbo Gong, Yuying Zhang, Xue Mi, Rong Xiang, Mianzhi Zhang*, and Xiaoyue Tan,* Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1. Biochim Biophys Acta-molecular basis of disease, 2019. 1865(9): p. 2267-2275.

Projects

1.       National Natural Science Foundation of China (82000708), The mechanism of Legumain on inhibiting renal interstitial fibrosis via sustaining lysosomal homeostasis,2021-2023

Teaching

Pathology