Research Focus

1. The role of noncoding RNA in various cardiovascular diseases, including Pulmonary Arterial Hypertension, PAH.

2. Circular RNA delivery strategies to the PAH mice models

3. Molecular mechanisms underlying Diabetes, Sepsis Shock and alcoholic liver disease.

Education

Ph.D., School of Pharmacy, Harbin Medical University, China, 2011,

MS, School of Life Science, Heilongjiang University, China,2005

BS, School of Life Science, Heilongjiang University, China, 2001

Professional experiences

10/2020-present, Associate Professor, School of Medicine, Nankai University, China;

09/2017-10/2020, Professor, School of Pharmacy, Harbin Medical University, China;

05/2014-02/2015, Research Scholar, Vascular Biology Section, Department of Medicine, Boston University, Boston, MA, USA;

05/2012-05/2014, Postdoctoral fellowship, Department of Biology, Georgia State University, GA, USA;

09/2011-09/2017, Associate Professor, School of Pharmacy, Harbin Medical University, China;

09/2008-09/2011, Lecturer, School of Pharmacy, Harbin Medical University, China;

09/2005-09/2007, Assistant Professor, School of Pharmacy, Harbin Medical University, China.

Selected Publications (*corresponding author, #first author)

[1]    Jin X, Wu Y, Cui N, Li SS. (2020) Methylglyoxal-induced miR-223 suppresses rat vascular KATP channel activity by downregulating Kir6.1 mRNA in carbonyl stress. Vascul Pharmacol. May-Jun 2020;128-129:106666. doi: 10.1016/j.vph.2020.106666. Epub 2020 Mar 6.

[2]    Jin X, Xu Y, Guo M, Sun Y, Ding J, Li L, Zheng X, Li S, Yuan D, Li SS, hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension, Molecular Therapy: Nucleic Acid (2020), doi: https://doi.org/10.1016/ j.omtn.2020.09.029.

[3]    Li S, Cui N, Yang Y, Trowe C, Wei Y, Wu Y, Zhang S, Jin X and Jiang C. (2015) Impairments of the vascular KATP channel imposes fatal susceptibility to experimental diabetes due to multi-organ injuries. Journal of Cellular Physiology, Dec;230 (12):2915-26.

[4]    Wu Y*, Li S*, Jin X, Cui N and Jiang C. (2015) Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle. Vascular Pharmacology, Aug;71:192-200. (equal first author)

[5]    Li S, Wu Y, Jin X, Jiang C. (2015) The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxal. Am J Physiol Cell Physiol, Jan 15; 308(2):C139-45.

Teaching

Pharmaceutical Molecular Biology

Biotechnological Pharmaceutics

Oral Microbiology

Research Grants

[1]    National Natural Science foundation of China. 2018-2021

[2]    Science Foundation of Education Department of Heilongjiang Provence. 2013-2015

[3]    National Natural Science foundation of China. 2012-2014

[4]    Scientific Research Foundation of Heilongjiang Health Department. 2009-2012

[5]    Science Foundation of Education Department of Heilongjiang Provence. 2006-2008