Zhi Qi

Zhi Qi

Work Address:  Department of Molecular Pharmacology, School of Medicine

Telephone:  022-23509877


E-mail:  qizhi@nankai.edu.cn


2002.4-2006.3    Department of Surgery, School of Medicine, Kyoto University, Japan; PhD                                       

2000.12-2002.3   Institute for Frontier Medical Sciences, Kyoto University, Japan;                                                Research Student; 

1995.9-2000.7    School of Clinical Medicine, West China University of Medical Sciences, China; Undergraduate



Positions and Employment:

2016.12-          School of Medicine, Nankai University;    Professor,

2009.12-2016.12   School of Medicine, Nankai University;    Associate Professor,

2008.4-2009.11    Department of Organ Reconstruction,

Institute for Frontier Medical Sciences,     Researcher


2006.4-2008.3     Department of Organ Reconstruction,

Institute for Frontier Medical Sciences,     Lecturer




1.      UndergraduateHistology and Embryology

2.      GraduateReview of Human Major Diseases


Research Interest:


1.      Pharmacology of Natural Products

2.      Molecular Mechanism of Cardiovascular Diseases

3.      Molecular Mechanism of Endocrine Diseases

4.      Molecular Mechanism of Cancer

5.      Transplantation


Research Support (in past 5 years):


1.      The National Natural Science Foundation of China; Syringaresinol attenuates diabetic cardiomyopathy-induced myocardial injury via Caveolin-1/Keap1/ Nrf2/HO-1 signaling pathway (No. 82172170); 2022.1-2025.12; 550,000CNY; Project Principal

2.      The Technical Envoy for Enterprises of Tianjin Natural Science Foundation; VEGF-B detection for cardiovascular diseases (No. 20YDTPJC00250); 2020.10-2021.9; 50,000CNY;Project Principal

3.      Tianjin Natural Science Foundation; The role of GSDME in diabetic cardiomyopathy (No. 20JCYBJC01260); 2020.4-2023.3; 200,000CNY; Project Principal

4.      Tianjin Natural Science Foundation; Molecular mechanism of stathmin phosphorylation regulated by MAPK chemotherapy-induced PGCCs formation and drug resistance (No. 20JCYBJC01230) ; 2020.4-2023.3; 200,000CNY; Participation (50%, 100,000 CNY)

5.      The National Natural Science Foundation of China; Resveratrol attenuates myocardial ischemia reperfusion injury through the synergistic effect of VEGF-B and SIRT1 signaling pathway (No. 81971887); 2020.1-2023.12; 550,000CNY; Project Principal

6.      Key Laboratory Open Project Fund of Emergency and Trauma of Ministry of Education; The role of GSDME in diabetic nephropathy (No. KLET-201906); 2020.1-2021.12; 80,000CNY;Project Principal

7.      Research Fund for Nankai University; The molecular mechanism for resveratrol during myocardial ischemia-reperfusion process (No. 68020374); 2019.1-2020.12; 150,000CNY; Project Principal

8.      The Key Program of Tianjin Natural Science Foundation; Resveratrol attenuates myocardial ischemia-reperfusion injury via the up-regulation of VEGF-B (No. 16JCZDJC35600); 2016,4-2019.3; 200,000CNY; Project Principal

9.      The National Basic Research Program of China (973 Program); Study of molecular nutrition mechanism and intervention of metabolic syndrome in China (No.2015CB553600); 2015.1-2019.12; 35,000,000 CNY; Participation (3%, 1,150,000CNY)


Selective Publication (in past 5 years):


* Corresponding Author


1.      Feng LF, Li GR, An JL, Liu C, Zhu XL, Xu Y, Gao Y, Li J, Liu J, Yan J, Wang YC, Ren JL*, Yang L*, Qi Z* Exercise training protects against heart failure via expansion of myeloid-derived suppressor cells through regulating IL-10/STAT3/S100A9 pathway. Circ.-Heart Fail. (In press)

2.      An JL, Feng LF, Ren JL, Li YF, Li GR, Liu C, Yao Y, Yao Y, Jiang ZC, Gao Y, Xu Y, Wang YC, Li J, Liu J, Cao L, Qi Z*, Yang L* Chronic psychological stress promotes breast carcinoma metastasis by mobilizing myeloid-derived suppressor cells through activating β-adrenergic signaling. Oncoimmunology (In press)


3.      Liu RQ, Liu YS, Liu C, Gao AJ, Wang L, Tang HX, Wu Q, Wang X, Tian DR*, Qi Z*, Shen YN* NEK7-mediated activation of NLRP3 inflammasome is coordinated by potassium efflux/Syk/JNK signaling during Staphylococcus aureus infection. Front Immunol. 12:7473702021.

4.      Shi ZY, Gao Y, Feng LF, Tian WC, Dou ZH, Liu C, Liu J, Xu Y, Wang YC, Yan J, Wu Q, Li J, Yang L, Zhang ZC*, Yang J*, Qi Z* TR35 exerts anti-tumor effects by modulating MAPK and STAT3 signaling in lung cancer cells. Front Cell Developmental Biol. 9:723346; 2021.

5.      Gao AJ, Tang HX, Zhang Q, Liu RQ, Wang L, Liu YS, Qi Z*, Shen YN* Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection. J Microbiol. 59:681-692; 2021.

6.      Yang YN, Tian WC, Yang L, Zhang Q, Zhu MM, Liu YS, Li J, Yang L, Liu J, Shen YN*, Qi Z* Gemcitabine potentiates antitumor effect of resveratrol on pancreatic cancer via downregulation of VEGFB. J Cancer Res Clin. 147: 93–103; 2021.

7.      Li GR, Yang L, Feng LF, Yang J, Li YF, An JL, Li DH, Xu Y, Gao Y, Li J, Liu J,Yang L*, Qi Z* Syringaresinol protects against type 1 diabetic cardiomyopathy by alleviating inflammation responses, cardiac fibrosis, and oxidative stress. Mol Nutr Food Res. 64:e2000231; 2020. This work was selected for cover story in the Sep 2020 issue of MNFR (Top journal in the nutrition)

8.      Tian XX, Zhang SZ, Zhang Q, Kang LC, Ma CZ, Feng LF, Li SY, Li J, Yang L, Liu J, Qi Z*, Shen YN* Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma. J Nutr Biochem. 85:1084892020.

9.      Li YF, Feng LF, Li GR, An JL, Zhang SZ, Li J, Liu J, Ren JL, Yang L*, Qi Z* Resveratrol prevents ISO-induced myocardial remodeling associated with regulating polarization of macrophages through VEGF-B/AMPK/NF-kB pathway. Int Immunopharmacol 84: 106508; 2020.

10.  Tian WC, Yang L, Liu YS, He JX, Yang L, Zhang Q, Liu F, Li J, Liu J, Sumi S, Shen YN*, Qi Z* Resveratrol attenuates doxorubicin-induced cardiotoxicity in rats by up-regulation of VEGF-B. J Nutr Biochem 79: 108132; 2020.

11.  Feng LF, Ren JL, Li YF, Yang GF, Kang LC, Zhang SZ, Ma CZ, Li J, Liu J, Yang L*, Qi Z* Resveratrol protects against isoproterenol induced myocardial infarction in rats through VEGF-B/AMPK/eNOS/NO signaling pathway. Free Radic Bio Med. 10: 1-19; 2018.

12.  Wang X, Yang L, Kang L, Li J, Yang L, Zhang J, Liu J, Zhu M, Zhang Q, Shen Y, Qi Z*. Metformin attenuates myocardial ischemia-reperfusion injury via up-regulation of antioxidant enzymes. PLoS One. 12:e0182777; 2017.

13.  Yang L, Zhang Y, Zhu MM, Zhang Q, Wang XL, Wang YJ, Zhang JC, Li J, Yang L, Liu J, Liu F, Yang YN, Kang LC, Shen YN, Qi Z*. Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B. Free Radic Bio Med. 101: 1-9; 2016.

14.  Zhu MM, Zhang Q, Wang XL, Kang LC, Yang YN, Liu YS, Yang L, Li J, Yang L, Liu J, Li Y, Zu LL, Shen YN, Qi Z*. Metformin potentiates anti-tumor effect of resveratrol on pancreatic cancer by down-regulation of VEGF-B signaling pathway. Oncotarget. 7: 84190-84200; 2016.


Honors and Awards:


2021.9        Excellent Teacher Award of Nankai University

2014.8        Young Investigator Award of 2014 International Symposium of Materials on Regenerative Medicine


Social Work:


Guest Editor of Frontiers in Cell and Developmental Biology

Reviewer of National Natural Science Foundation of China

Vice President of Tianjin Anatomy Association