Biography

Research Focus

1. Role of non-coding RNAs in cancer stem cells

2. Molecular mechanisms of intestinal stem cell self-renewal

Education

2013-2019, Ph.D., Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences

2009-2013, Bachelor, Biotechnology, College of Life Science, Nankai University

Professional Experience

2019-Present, Lecturer in School of Medicine, Nankai University

Research

Publications

1.   Wu J^#, Zhu P^#, Lu T^#, Du Y^#, Wang Y^#, He L, Ye B, Liu B, Wang J, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, Fan Z. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 70(5), 918-929, 2019.

2.   Zhu P^#, Wu J#, Wang Y^#, Zhu X^#, Lu T^#, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. LncGata6 maintains stemness of intestinal stem cells and drives intestinal tumorigenesis. Nat Cell Biol. 20(10),1134-1144, 2018.

3.   Zhu P^#, Zhu X^#, Wu J#, He L^#, Lu T^#, Liu B, Wang Y, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 20(2), 183-194, 2019.

4.   Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y, Fan Z. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. Online ahead of print.

5.   Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y, Fan Z. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 216(11), 2653-2668, 2019.

6.   Wang Y, Zhu P, Zhu X, Wang J, Luo J, Meng S, Wu J, He L, Du Y, He L, Chen R, Tian Y, Fan Z. Long noncoding RNA LncHand2 promotes liver regeneration via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 69(4), 861-872, 2018.

7.   Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R, Tian Y, Fan Z. LncKdm2b controls pluripotency of embryonic stem cells and early embryogenesis via activation of transcription factor Zbtb3.EMBO J. 37(8), e97174, 2018.

8.   Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 8(1), 1518, 2017.

9.   Yan X, Zhang D, Wu W, Wu S, Qian J, Hao Y, Yan F, Zhu P, Wu J, Huang G, Huang Y, Luo J, Liu X, Liu B, Chen X, Du Y, Chen RS, Fan Z. Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a. Cancer Res. 77(23), 6704-6716, 2017.

10.  Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, Du Y, Wu J, Meng S, Tian Y, Fan Z. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 8(1), 231, 2017.

11.  Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R, Tian Y, Fan Z. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 18(5), 499-508, 2017.

12.  Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 7, 13608, 2016.

13.  Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 23(7), 631-639, 2016.

14.  Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J Clin Invest. 125(10), 3795-3808, 2015.

Projects

1. National Natural Science Foundation of China (#82003092), Study on the Molecular Mechanisms of COMMD3 in the Intraperitoneal Transcoelomic Metastasis of Ovarian Cancer, 2021-2023

Teaching

1. Undergraduate: Medical Immunology

2. Master: Medical Immunology