Research Focus

1.     Application of Nbs on food safety inspection.

2.     Development of specific Nbs against tumor targets for diagnosis and therapy.

3.     The intervention effect of food nutrients on immunology, especially on innate immunity of macrophages.

Education

Ph.D., Bio-engineering sciences, Vrije Universiteit Brussel, Belgium, 2018

Ph.D., Pharmaceutical Engineering, Tianjin University, China, 2017

M.S., Biochemical Engineering, Tianjin University, China, 2013

B.S., Tianjin University, Bio-Engineering, 2009

Professional Experience

2018 - present, Lecturer in School of Medicine, Nankai University

Selected Publications

1.   Hu Y, Liu C,Muyldermans S. Nanobody-based delivery systems for diagnosis andtargeted tumor therapy. Frontiers in Immunology, 2017, 8:1442.

2.   Hu Y, Romão E,Vertommen D, Vincke C, Morales-Yánez F, Gutiérrez C, Liu C,Muyldermans S. Generation of Nanobodies against SlyD and developmentof tools to eliminate this bacterial contaminant from recombinantproteins. Protein Expression and Purification, 2017, 137:64-76.

3.   Hu Y, Liu J, HuangH. Recent agents targeting HIF-1alpha for cancer therapy. Journal ofCellular Biochemistry. 2013, 114:498-509.

4.   Cawez F, Duray E,Hu Y, Vandenameele J, Romão E, Vincke C, Galleni M, Muyldermans S,Vandevenne M. Combinatorial design of a nanobody that specificallytargets structured RNAs. Journal of Molecular Biology, 2018, 11:1652-1670.

5.   Romão E,Morales-Yánez F, Hu Y, Crauwels M, De Pauw P, Hassanzadeh GG,Devoogdt N, Ackaert C, Vincke C, Muyldermans S. Identification ofuseful nanobodies by phage display of immune single domain librariesderived from camelid heavy chain antibodies. Current PharmaceuticalDesign, 2016, 22:6500-6518.

6.   Li M, Fan X, Liu J,Hu Y, Huang H. Selection by phage display of nanobodies directedagainst hypoxia inducible factor-1alpha (HIF-1alpha). AppliedBiochemistry and Biotechnology, 2015, 62:738-745.

7.   Huang H, Song C,Yang Z, Dong Y, Hu Y, Gao F. Identification of the replicationorigins from Cyanothece ATCC 51142 and their interactions with theDnaA protein: from in silico to in vitro studies. Frontiers inMicrobiology, 2015, 6:1370.

8.    Fan X, Hu Y, HuangH. Nanobodies: Novel biomedical vehicles in targeting tumor. Journalof Chemical and Pharmaceutical Research, 2014, 6:458-462.

Projects

National Natural Science Foundation of China (#31901779)