Specialization: 

Neurodevelopment disorder; Ion channel; Neuroscience; Epigenetic modifications for the pathogenesis of vascular disease.

Education:

Ph.D. (2008) clinical pharmacology, Graduate School of Medicine,Dentistry and Pharmaceutical Sciences, Okayama University

Professional Experience:

Associate Research Scientist (2014-2018): Yale University School of Medicine

Postdoc. (2010-2014): Georgia State University

Research Scientist (2009-2010): Okayama University

Selected Publications:

1. Liang S, Sun Y, Li L, Long Y, Wang M, Yang H, Li C, Wang Y, Li S, Chen X, Jin X. Progesterone changes the pregnancy-induced adaptation of cardiomyocyte Kv2.1 channels via microRNA-29b. cardiovascular therapeutics. 7145699 (2022).

2. Li S, Liang S, Long Y, Chen X, Jin X. New insights into the pathology of pulmonary arterial hypertension: implication of hsa_circWDR37_016. Cardiovascular Therapeutics.7292034 (2022).

3. Ghosh DD, Lee D, Jin X, Horvitz H.R., Nitabach M.C. elegans discriminates colors to guide foraging. Science (2021)

4. Jin X, Xu Y, Guo M, Sun Y, Ding J, Li L, Zheng X, Li S, Yuan D, Li SS. hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension. Molecular Therapy - Nucleic Acids. 23：5，1007-1009 (2021)

5. Jin X, Wu Y, Cui N, Jiang C, Li SS,Methylglyoxal-induced miR-223 suppresses rat vascular KATP channel activity by downregulating Kir6.1 mRNA in carbonyl stress. Vascular Pharmacology. 128-129 (2020).

6. Pan Y, Sitaraman D, Chen N, Jin X, Chen D, Nitabach MN, Baker B. Sexually dimorphic neural substrates for prioritizing sleep and reproductive behaviors in Drosophila. Nature Communications .8: 154 (2017).

7. Jin X, Li SS, Bondy B, Zhong W, Oginsky M, Yang Wu, Johnson C, Zhang S, Cui N, Jiang C. Optogenetic identification of local GABAergic signaling in the locus coeruleus. PLoS ONE. Jan 19; 11(1):e0146470 (2016).

8. Jin H, Li Z, Takatori S, Koyama T, Jin X, Zamami Y, Kawasaki H, Sun P. Vascular Responses to Compound 48/80 in Rat Mesenteric Vascular Beds. Canadian Journal of Physiology and Pharmacology. 2016 Jun;94(6):620-6.

9. Li SS, Wu Y, Jin X , Jiang C. The SUR2B subunit of rat vascular KATP channel is targeted by miR-9a-3p induced by prolonged exposure to methylglyoxal. American J Physiology. 308: C139–C145, (2015).

10. Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach M. Homeostatic control of sleep by synaptic microcircuits in the Drosophila mushroom body. Current Biology.16; 25(22):2915-27 (2015).

11. Qu L, Yu L, Wang Y, Jin X, Zhang Q, Lu P, Yu X, Cui N, Jiang C, Zhu D. Inward rectifier K+ currents are regulated by CaMKII in endothelial cells of primarily cultured bovine pulmonary arteries. PLoS ONE. PONE-D-15-12526R2 (2015).

12. Zhong W, Cui N, Jin X, Oginsky M, Wu Y, Zhang S, Bondy B, Johnson C, Jiang C. Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons. J Biol Chem. 290(30):18400-11 (2015).

13. Wu Y, Li SS, Jin X, Cui N, Zhang S Jiang C. Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle. Vascul Pharmacol. 71:192-200 (2015).

14. Li SS, Cui N, Yang Y, Trower C, Wei YM, Wu Y, Zhang S, Jin X, Jiang C. Impairments of the vascular KATP channel imposes fatal susceptibility to experimental diabetes due to multi-organ injuries. Journal of Cellular Physiology. 230(12):2915-26 (2015).

15. Yang Y, Jin X, Jiang C. S-glutathionylation of ion channels: insights into the regulation of channel function, thiol modification crosstalk and mechanosensing. Antioxidants & Redox Signaling. 20(6):937-51 (2014).

16. Jin X, Zhong W, Jiang C. Time-dependent modulation of GABAA-ergic synaptic transmission by allopregnanolone in locus coeruleus neurons of Mecp2-null mice. American J Physiology. 305:C1151-60 (2013).

17. Jin X, Cui N, Zhong W, Jin XT, Jiang C. GABA-ergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice. American J Physiol. 304:844-857 (2013).

18. Jin X, Yu L, Zhang S, Wu Y, Shi ZD, Chen XF, Yang Y, Zhang XL, Jiang C. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol. 590:5335-5348 (2012).

19. Jin XT, Cui N, Zhong W, Jin X, Wu Z, Jiang C. Pre- and postsynaptic modulations of HNs by α-adrenoceptor activation in wild-type and Mecp2−/Y mice. American J Physiology. 305: 1080-90 (2013).

20. Wang YJ, Yu L, Cui N, Jin X, Zhu D, Jiang C. Differential sensitivities of the vascular KATP channel to various PPAR activators. Biochemical Pharmacology. 85: 1495-1503 (2013).

Projects

National Natural Science Foundation of China

The Open Fund of Tianjin Central Hospital of Gynecology Obstetrics / Tianjin Key Laboratory of human development and reproductive regulation,

Tianjin Municipal Science and Technology Project

Teaching：

Pharmacology (Clinical and Oral Specialty)

Pharmacology (International Student Course)

Oral Clinical Pharmacy (Oral Specialty)

Medical Physiology Laboratory (Clinical and Oral Specialty)

Professional English (Graduate Course)

Experimental Animal Science (Graduate Course)

Academic Writing Course (Doctoral Course)

International Perspective and Personal Growth (Graduate and Undergraduate Students).